Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

BACKGROUND: The complex pathophysiology of Alzheimer’s disease (AD) hampers the development of effective treatments. Attempts to prevent neurodegeneration in AD have failed so far, highlighting the need for further clarification of the underlying cellular and molecular mechanisms. Neuroinflammation...

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Detalles Bibliográficos
Autores principales: Ruiz-Pérez, Gonzalo, Ruiz de Martín Esteban, Samuel, Marqués, Sharai, Aparicio, Noelia, Grande, M. Teresa, Benito-Cuesta, Irene, Martínez-Relimpio, Ana M., Arnanz, M. Andrea, Tolón, Rosa M., Posada-Ayala, María, Cravatt, Benjamin F., Esteban, José A., Romero, Julián, Palenzuela, Rocío
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482614/
https://www.ncbi.nlm.nih.gov/pubmed/34587978
http://dx.doi.org/10.1186/s12974-021-02276-y

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