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Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy

BACKGROUND: Hypoxia is a characteristic of solid tumors that can lead to tumor angiogenesis and early metastasis, and addressing hypoxia presents tremendous challenges. In this work, a nanomedicine based on oxygen-absorbing perfluorotributylamine (PFA) and the bioreductive prodrug tirapazamine (TPZ)...

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Detalles Bibliográficos
Autores principales:	Chen, Hongfang, Fu, You, Feng, Kai, Zhou, Yifan, Wang, Xin, Huang, Haohan, Chen, Yan, Wang, Wenhao, Xu, Yuanjing, Tian, Haijun, Mao, Yuanqing, Wang, Jinwu, Zhang, Zhiyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482624/ https://www.ncbi.nlm.nih.gov/pubmed/34592996 http://dx.doi.org/10.1186/s12951-021-01013-0

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