A gene-environment induced epigenetic program initiates tumorigenesis

Tissue damage increases cancer risk through poorly understood mechanisms1. In the pancreas, pancreatitis associated with tissue injury collaborates with activating mutations in the Kras oncogene to dramatically accelerate the formation of early neoplastic lesions and ultimately pancreatic cancer(2,3...

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Detalles Bibliográficos
Autores principales: Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L.V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482641/
https://www.ncbi.nlm.nih.gov/pubmed/33536616
http://dx.doi.org/10.1038/s41586-020-03147-x

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