METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

BACKGROUND: N6-methyladenosine (m(6)A) modification of RNA influences fundamental aspects of RNA metabolism and m(6)A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m(6)A modification in the pathogenesis of Alzheimer disease (AD). METHODS:...

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Detalles Bibliográficos
Autores principales: Zhao, Fanpeng, Xu, Ying, Gao, Shichao, Qin, Lixia, Austria, Quillan, Siedlak, Sandra L., Pajdzik, Kinga, Dai, Qing, He, Chuan, Wang, Wenzhang, O’Donnell, James M., Tang, Beisha, Zhu, Xiongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482683/
https://www.ncbi.nlm.nih.gov/pubmed/34593014
http://dx.doi.org/10.1186/s13024-021-00484-x

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