Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum

[Image: see text] Four polyketide–amino acid derivatives, pardinumones A–D (1–4), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dic...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hui-Xiang, Ma, Jin-Tao, He, Juan, Li, Zheng-Hui, Huang, Rong, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482770/
https://www.ncbi.nlm.nih.gov/pubmed/34604687
http://dx.doi.org/10.1021/acsomega.1c04418
_version_ 1784576979972915200
author Yang, Hui-Xiang
Ma, Jin-Tao
He, Juan
Li, Zheng-Hui
Huang, Rong
Feng, Tao
Liu, Ji-Kai
author_facet Yang, Hui-Xiang
Ma, Jin-Tao
He, Juan
Li, Zheng-Hui
Huang, Rong
Feng, Tao
Liu, Ji-Kai
author_sort Yang, Hui-Xiang
collection PubMed
description [Image: see text] Four polyketide–amino acid derivatives, pardinumones A–D (1–4), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dichroism (ECD) and NMR with sorted training set (STS) protocol analysis. Compounds 1–4 exhibited antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with MIC values in the range of 6.25–50 μg/mL.
format Online
Article
Text
id pubmed-8482770
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-84827702021-10-01 Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum Yang, Hui-Xiang Ma, Jin-Tao He, Juan Li, Zheng-Hui Huang, Rong Feng, Tao Liu, Ji-Kai ACS Omega [Image: see text] Four polyketide–amino acid derivatives, pardinumones A–D (1–4), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dichroism (ECD) and NMR with sorted training set (STS) protocol analysis. Compounds 1–4 exhibited antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with MIC values in the range of 6.25–50 μg/mL. American Chemical Society 2021-09-15 /pmc/articles/PMC8482770/ /pubmed/34604687 http://dx.doi.org/10.1021/acsomega.1c04418 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yang, Hui-Xiang
Ma, Jin-Tao
He, Juan
Li, Zheng-Hui
Huang, Rong
Feng, Tao
Liu, Ji-Kai
Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title_full Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title_fullStr Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title_full_unstemmed Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title_short Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
title_sort pardinumones a–d: antibacterial polyketide–amino acid derivatives from the mushroom tricholoma pardinum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482770/
https://www.ncbi.nlm.nih.gov/pubmed/34604687
http://dx.doi.org/10.1021/acsomega.1c04418
work_keys_str_mv AT yanghuixiang pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT majintao pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT hejuan pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT lizhenghui pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT huangrong pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT fengtao pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum
AT liujikai pardinumonesadantibacterialpolyketideaminoacidderivativesfromthemushroomtricholomapardinum

Ejemplares similares