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Intracranially injectable multi-siRNA nanomedicine for the inhibition of glioma stem cells

BACKGROUND: Nanoparticle siRNA-conjugates are promising clinical therapeutics as indicated by recent US-FDA approval. In glioma stem cells (GSC), multiple stemness associated genes were found aberrant. We report intracranially injectable, multi-gene-targeted siRNA nanoparticle gel (NPG) for the comb...

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Detalles Bibliográficos
Autores principales:	Manju, Cheripelil Abraham, Jeena, Kottarapat, Ramachandran, Ranjith, Manohar, Maneesh, Ambily, Anna Mathew, Sajesh, Koythatta Meethalveedu, Gowd, Genekehal Siddaramana, Menon, Krishnakumar, Pavithran, Keechilat, Pillai, Ashok, Nair, Shantikumar V, Koyakutty, Manzoor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482790/ https://www.ncbi.nlm.nih.gov/pubmed/34604750 http://dx.doi.org/10.1093/noajnl/vdab104

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