Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India

PURPOSE: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. METHODS: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time q...

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Detalles Bibliográficos
Autores principales: Jeyaprakash, Kumar, Shanthini, Thennarasu, Kim, Usha, Muthukkaruppan, Veerappan, Vanniarajan, Ayyasamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482879/
https://www.ncbi.nlm.nih.gov/pubmed/34304188
http://dx.doi.org/10.4103/ijo.IJO_106_21
Descripción
Sumario:PURPOSE: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. METHODS: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR. RESULTS: Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome. CONCLUSION: Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.

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