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Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy

BACKGROUND: Our previous studies revealed a critical role of a novel CTLA4-protein kinase C-eta (PKCη) signaling axis in mediating the suppressive activity of regulatory T cells (Tregs) in antitumor immunity. These studies have employed adoptive transfer of germline PKCη-deficient (Prkch(−/−)) Tregs...

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Detalles Bibliográficos
Autores principales:	Liu, Hsin-Yu, Pedros, Christophe, Kong, Kok-Fai, Canonigo-Balancio, Ann J, Xue, Wen, Altman, Amnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483050/ https://www.ncbi.nlm.nih.gov/pubmed/34588224 http://dx.doi.org/10.1136/jitc-2021-002792

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