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Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report

Patient: Female, 39-year-old Final Diagnosis: Primary neuroendocrine small cell carcinoma of the breast Symptoms: Left breast mass • recurrent mastitis Medication: — Clinical Procedure: — Specialty: Pathology • Radiology OBJECTIVE: Rare disease BACKGROUND: Primary breast small cell neuroendocrine ca...

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Autores principales: Gharaibeh, Maha M., Elobeid, Eyhab A., El-heis, Mwaffaq A., Bataineh, Lama A., Alorjani, Mohammed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483060/
https://www.ncbi.nlm.nih.gov/pubmed/34570746
http://dx.doi.org/10.12659/AJCR.932274
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author Gharaibeh, Maha M.
Elobeid, Eyhab A.
El-heis, Mwaffaq A.
Bataineh, Lama A.
Alorjani, Mohammed S.
author_facet Gharaibeh, Maha M.
Elobeid, Eyhab A.
El-heis, Mwaffaq A.
Bataineh, Lama A.
Alorjani, Mohammed S.
author_sort Gharaibeh, Maha M.
collection PubMed
description Patient: Female, 39-year-old Final Diagnosis: Primary neuroendocrine small cell carcinoma of the breast Symptoms: Left breast mass • recurrent mastitis Medication: — Clinical Procedure: — Specialty: Pathology • Radiology OBJECTIVE: Rare disease BACKGROUND: Primary breast small cell neuroendocrine carcinoma is a rare subtype of breast cancer with about 57 cases reported in the literature. This rare type of cancer represents about 0.1% of breast carcinomas. Recently, the World Health Organization defined this type of cancer as a separate entity from other breast cancer types. The diagnosis of this type of cancer in the breast is difficult because the histological pattern is similar to the small cell neuroendocrine carcinoma of other more common primary sites of origin, including the lung. CASE REPORT: A 39-year-old woman presented to our hospital with a left breast mass and recurrent mastitis. Physical examination revealed a painless lump in her left breast with a brown-colored discharge from the nipple, and her child refused breastfeeding from the left breast. A high-density well-defined rounded mass was observed upon mammography in the upper lateral aspect of the left breast. This mass lesion appeared hypoechoic with no posterior acoustic shadowing on ultrasound scan. A core-needle biopsy of the mass was performed and the diagnosis of small cell neuroendocrine carcinoma was rendered after histopathologic examination. Positron emission tomography scanning was helpful in the exclusion of primary origin from other organ sites; thus, the primary breast origin of the tumor was confirmed. CONCLUSIONS: This case report provides a comprehensive approach to diagnose this type of small cell carcinoma originating primarily in the breast. The suspicion of this type of breast cancer should be raised if there is presence of characteristic histopathologic findings with the exclusion of any primary origin from other organ sites by the help of imaging studies.
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spelling pubmed-84830602021-10-18 Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report Gharaibeh, Maha M. Elobeid, Eyhab A. El-heis, Mwaffaq A. Bataineh, Lama A. Alorjani, Mohammed S. Am J Case Rep Articles Patient: Female, 39-year-old Final Diagnosis: Primary neuroendocrine small cell carcinoma of the breast Symptoms: Left breast mass • recurrent mastitis Medication: — Clinical Procedure: — Specialty: Pathology • Radiology OBJECTIVE: Rare disease BACKGROUND: Primary breast small cell neuroendocrine carcinoma is a rare subtype of breast cancer with about 57 cases reported in the literature. This rare type of cancer represents about 0.1% of breast carcinomas. Recently, the World Health Organization defined this type of cancer as a separate entity from other breast cancer types. The diagnosis of this type of cancer in the breast is difficult because the histological pattern is similar to the small cell neuroendocrine carcinoma of other more common primary sites of origin, including the lung. CASE REPORT: A 39-year-old woman presented to our hospital with a left breast mass and recurrent mastitis. Physical examination revealed a painless lump in her left breast with a brown-colored discharge from the nipple, and her child refused breastfeeding from the left breast. A high-density well-defined rounded mass was observed upon mammography in the upper lateral aspect of the left breast. This mass lesion appeared hypoechoic with no posterior acoustic shadowing on ultrasound scan. A core-needle biopsy of the mass was performed and the diagnosis of small cell neuroendocrine carcinoma was rendered after histopathologic examination. Positron emission tomography scanning was helpful in the exclusion of primary origin from other organ sites; thus, the primary breast origin of the tumor was confirmed. CONCLUSIONS: This case report provides a comprehensive approach to diagnose this type of small cell carcinoma originating primarily in the breast. The suspicion of this type of breast cancer should be raised if there is presence of characteristic histopathologic findings with the exclusion of any primary origin from other organ sites by the help of imaging studies. International Scientific Literature, Inc. 2021-09-27 /pmc/articles/PMC8483060/ /pubmed/34570746 http://dx.doi.org/10.12659/AJCR.932274 Text en © Am J Case Rep, 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Gharaibeh, Maha M.
Elobeid, Eyhab A.
El-heis, Mwaffaq A.
Bataineh, Lama A.
Alorjani, Mohammed S.
Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title_full Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title_fullStr Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title_full_unstemmed Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title_short Radiological and Histological Correlation in Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report
title_sort radiological and histological correlation in small cell neuroendocrine carcinoma of the breast: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483060/
https://www.ncbi.nlm.nih.gov/pubmed/34570746
http://dx.doi.org/10.12659/AJCR.932274
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