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Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan

BACKGROUND: Human immunodeficiency virus (HIV) infection in pregnant women has an important role in its spread to the pediatric population through vertical transmission. Effective utilization of Prevention of Parent to Child Transmission (PPTCT) services can reduce this spread. This study aims to de...

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Autores principales: Verma, Usha, Asopa, Vishakha, Gupta, Eshank, Gupta, Ekta, Lal, Parmeshwar, Prakash, Prabhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483135/
https://www.ncbi.nlm.nih.gov/pubmed/34660404
http://dx.doi.org/10.4103/jfmpc.jfmpc_847_19
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author Verma, Usha
Asopa, Vishakha
Gupta, Eshank
Gupta, Ekta
Lal, Parmeshwar
Prakash, Prabhu
author_facet Verma, Usha
Asopa, Vishakha
Gupta, Eshank
Gupta, Ekta
Lal, Parmeshwar
Prakash, Prabhu
author_sort Verma, Usha
collection PubMed
description BACKGROUND: Human immunodeficiency virus (HIV) infection in pregnant women has an important role in its spread to the pediatric population through vertical transmission. Effective utilization of Prevention of Parent to Child Transmission (PPTCT) services can reduce this spread. This study aims to determine the vertical transmission of HIV, the seroprevalence of HIV in antenatal women, demographic factors of seropositive women, and utilization of PPTCT services to minimize the risk of mother-to-child transmission. METHODS: This study was conducted to assess vertical transmission of HIV in the newborn of HIV pregnant women attending antenatal clinic (ANC) of a tertiary care hospital from August 2014 to December 2020. Pretest counseling, HIV testing, and posttest counseling were done as per National AIDS Control Organization (NACO) guidelines. Antiretroviral prophylaxis was given to seropositive women and their children. Analysis of demographic data of seropositive women and assessment of the utilization of PPTCT services were done according to available records. RESULTS: In the study time, 139,619 new antenatal registrations were there, 68.21% of women attended pretest counseling and of them, 95.28% gave consent for HIV testing. Out of which, 0.14% were reported as HIV seropositive in PPTCT (tested according to NACO guidelines). In the study time, a total of 188 HIV-positive deliveries were conducted in our institute. Out of which, 144 (76.6%) were ANC-booked patients and 44 (23.4%) were unbooked patients and directly came in labor, deliveries were conducted according to NACO guidelines and all newborns were given nevirapine syrup. All newborns were followed up until 18 months and in study time, 78 dry blood samples (DBSs) were sent for DNA polymerase chain reaction (PCR) detection and all were reported negative by the reference laboratory at AIIMS, New Delhi. CONCLUSIONS: Adherence to testing, treatment, and follow-up in the antenatal and postnatal period can minimize the risk of HIV transmission from mother to child.
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spelling pubmed-84831352021-10-14 Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan Verma, Usha Asopa, Vishakha Gupta, Eshank Gupta, Ekta Lal, Parmeshwar Prakash, Prabhu J Family Med Prim Care Original Article BACKGROUND: Human immunodeficiency virus (HIV) infection in pregnant women has an important role in its spread to the pediatric population through vertical transmission. Effective utilization of Prevention of Parent to Child Transmission (PPTCT) services can reduce this spread. This study aims to determine the vertical transmission of HIV, the seroprevalence of HIV in antenatal women, demographic factors of seropositive women, and utilization of PPTCT services to minimize the risk of mother-to-child transmission. METHODS: This study was conducted to assess vertical transmission of HIV in the newborn of HIV pregnant women attending antenatal clinic (ANC) of a tertiary care hospital from August 2014 to December 2020. Pretest counseling, HIV testing, and posttest counseling were done as per National AIDS Control Organization (NACO) guidelines. Antiretroviral prophylaxis was given to seropositive women and their children. Analysis of demographic data of seropositive women and assessment of the utilization of PPTCT services were done according to available records. RESULTS: In the study time, 139,619 new antenatal registrations were there, 68.21% of women attended pretest counseling and of them, 95.28% gave consent for HIV testing. Out of which, 0.14% were reported as HIV seropositive in PPTCT (tested according to NACO guidelines). In the study time, a total of 188 HIV-positive deliveries were conducted in our institute. Out of which, 144 (76.6%) were ANC-booked patients and 44 (23.4%) were unbooked patients and directly came in labor, deliveries were conducted according to NACO guidelines and all newborns were given nevirapine syrup. All newborns were followed up until 18 months and in study time, 78 dry blood samples (DBSs) were sent for DNA polymerase chain reaction (PCR) detection and all were reported negative by the reference laboratory at AIIMS, New Delhi. CONCLUSIONS: Adherence to testing, treatment, and follow-up in the antenatal and postnatal period can minimize the risk of HIV transmission from mother to child. Wolters Kluwer - Medknow 2021-08 2021-08-27 /pmc/articles/PMC8483135/ /pubmed/34660404 http://dx.doi.org/10.4103/jfmpc.jfmpc_847_19 Text en Copyright: © 2021 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Verma, Usha
Asopa, Vishakha
Gupta, Eshank
Gupta, Ekta
Lal, Parmeshwar
Prakash, Prabhu
Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title_full Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title_fullStr Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title_full_unstemmed Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title_short Vertical transmission of HIV, Where do we stand ? Study done in PPTCT center – in a tertiary level of hospital of Western Rajasthan
title_sort vertical transmission of hiv, where do we stand ? study done in pptct center – in a tertiary level of hospital of western rajasthan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483135/
https://www.ncbi.nlm.nih.gov/pubmed/34660404
http://dx.doi.org/10.4103/jfmpc.jfmpc_847_19
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