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Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis

Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threon...

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Autores principales: Kumar, Navneet, Mandal, Chandi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483559/
https://www.ncbi.nlm.nih.gov/pubmed/34603386
http://dx.doi.org/10.3389/fgene.2021.724149
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author Kumar, Navneet
Mandal, Chandi C.
author_facet Kumar, Navneet
Mandal, Chandi C.
author_sort Kumar, Navneet
collection PubMed
description Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. Since its involvement in several signaling pathways, its dysregulation is commonly reported in several cancers. Thus, targeting Akt could be an effective approach for cancer prevention and therapy. Cholesterol-lowering drugs have been found to affect the expression of Akt, and its activation in the cancer cells and thus have shown anticancer activity in different type of cancers. These drugs act on various signaling pathways such as PTEN/Akt, PI3k/Akt, Akt/NF-κB, Akt/FOXO1, Akt/mTOR, etc., which will be discussed in this article. This review article will discuss the significance of cholesterol in cancer cells, cholesterol-lowering drugs, the role of Akt in cancer cells, and the effects of cholesterol-lowering drugs on Akt in the prevention of therapy resistance and metastasis.
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spelling pubmed-84835592021-10-01 Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis Kumar, Navneet Mandal, Chandi C. Front Genet Genetics Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. Since its involvement in several signaling pathways, its dysregulation is commonly reported in several cancers. Thus, targeting Akt could be an effective approach for cancer prevention and therapy. Cholesterol-lowering drugs have been found to affect the expression of Akt, and its activation in the cancer cells and thus have shown anticancer activity in different type of cancers. These drugs act on various signaling pathways such as PTEN/Akt, PI3k/Akt, Akt/NF-κB, Akt/FOXO1, Akt/mTOR, etc., which will be discussed in this article. This review article will discuss the significance of cholesterol in cancer cells, cholesterol-lowering drugs, the role of Akt in cancer cells, and the effects of cholesterol-lowering drugs on Akt in the prevention of therapy resistance and metastasis. Frontiers Media S.A. 2021-09-16 /pmc/articles/PMC8483559/ /pubmed/34603386 http://dx.doi.org/10.3389/fgene.2021.724149 Text en Copyright © 2021 Kumar and Mandal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Kumar, Navneet
Mandal, Chandi C.
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title_full Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title_fullStr Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title_full_unstemmed Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title_short Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
title_sort cholesterol-lowering drugs on akt signaling for prevention of tumorigenesis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483559/
https://www.ncbi.nlm.nih.gov/pubmed/34603386
http://dx.doi.org/10.3389/fgene.2021.724149
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