Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells

We have extended our analyses of HDAC inhibitor biology in sarcoma. The multi-kinase inhibitor axitinib interacted with multiple HDAC inhibitors to kill sarcoma cells. Axitinib and HDAC inhibitors interacted in a greater than additive fashion to inactivate AKT, mTORC1 and mTORC2, and to increase Rap...

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Detalles Bibliográficos
Autores principales: Roberts, Jane L., Booth, Laurence, Poklepovic, Andrew, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483767/
https://www.ncbi.nlm.nih.gov/pubmed/34604061
http://dx.doi.org/10.3389/fonc.2021.723966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483767/
https://www.ncbi.nlm.nih.gov/pubmed/34604061
http://dx.doi.org/10.3389/fonc.2021.723966

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