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High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis

BACKGROUND: Morning cortisol levels have been reported to be elevated among patients with Alzheimer disease (AD). We perform a protocol for systematic review and meta-analysis to assess morning central or peripheral cortisol levels in AD patients as compared with cognitively normal individuals. METH...

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Detalles Bibliográficos
Autores principales: Yao, Zhuang, Liu, Bin, Wang, Yueyang, Dong, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483835/
https://www.ncbi.nlm.nih.gov/pubmed/34596132
http://dx.doi.org/10.1097/MD.0000000000027319
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author Yao, Zhuang
Liu, Bin
Wang, Yueyang
Dong, Xiaohong
author_facet Yao, Zhuang
Liu, Bin
Wang, Yueyang
Dong, Xiaohong
author_sort Yao, Zhuang
collection PubMed
description BACKGROUND: Morning cortisol levels have been reported to be elevated among patients with Alzheimer disease (AD). We perform a protocol for systematic review and meta-analysis to assess morning central or peripheral cortisol levels in AD patients as compared with cognitively normal individuals. METHODS: Studies were identified through systematic searches in August 2021 with no restrictions on date and time, language, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. Studies were identified using search terms related to cortisol, Alzheimer disease, and cognitive impairment. The study quality of included papers was evaluated using the “National Institutes of Health (NIH) quality assessment tool for observational cohort and cross-sectional studies.” Statistical analyses were performed using Stata (version 14, StataCorp, College Station, TX). RESULTS: The findings of this study will be submitted to peer-reviewed journals for publication. CONCLUSION: Morning cortisol was elevated in AD patients and may have diagnostic and prognostic values for AD.
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spelling pubmed-84838352021-10-04 High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis Yao, Zhuang Liu, Bin Wang, Yueyang Dong, Xiaohong Medicine (Baltimore) 5300 BACKGROUND: Morning cortisol levels have been reported to be elevated among patients with Alzheimer disease (AD). We perform a protocol for systematic review and meta-analysis to assess morning central or peripheral cortisol levels in AD patients as compared with cognitively normal individuals. METHODS: Studies were identified through systematic searches in August 2021 with no restrictions on date and time, language, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. Studies were identified using search terms related to cortisol, Alzheimer disease, and cognitive impairment. The study quality of included papers was evaluated using the “National Institutes of Health (NIH) quality assessment tool for observational cohort and cross-sectional studies.” Statistical analyses were performed using Stata (version 14, StataCorp, College Station, TX). RESULTS: The findings of this study will be submitted to peer-reviewed journals for publication. CONCLUSION: Morning cortisol was elevated in AD patients and may have diagnostic and prognostic values for AD. Lippincott Williams & Wilkins 2021-10-01 /pmc/articles/PMC8483835/ /pubmed/34596132 http://dx.doi.org/10.1097/MD.0000000000027319 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5300
Yao, Zhuang
Liu, Bin
Wang, Yueyang
Dong, Xiaohong
High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title_full High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title_fullStr High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title_full_unstemmed High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title_short High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
title_sort high cortisol and the risk of alzheimer disease: a protocol for systematic review and meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483835/
https://www.ncbi.nlm.nih.gov/pubmed/34596132
http://dx.doi.org/10.1097/MD.0000000000027319
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