Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure

Although hepatic involvement in light chain–associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension...

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Autores principales: Kim, Hyun Jae, Tomaszewski, Marcel, Lam, Eric C., Xiong, Wei, Moosavi, Sarvee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483873/
https://www.ncbi.nlm.nih.gov/pubmed/34604435
http://dx.doi.org/10.14309/crj.0000000000000479
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author Kim, Hyun Jae
Tomaszewski, Marcel
Lam, Eric C.
Xiong, Wei
Moosavi, Sarvee
author_facet Kim, Hyun Jae
Tomaszewski, Marcel
Lam, Eric C.
Xiong, Wei
Moosavi, Sarvee
author_sort Kim, Hyun Jae
collection PubMed
description Although hepatic involvement in light chain–associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension, with rapidly progressive liver failure, in the absence of hepatomegaly, secondary to systemic light chain–associated amyloidosis associated with multiple myeloma.
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spelling pubmed-84838732021-10-01 Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure Kim, Hyun Jae Tomaszewski, Marcel Lam, Eric C. Xiong, Wei Moosavi, Sarvee ACG Case Rep J Case Report Although hepatic involvement in light chain–associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension, with rapidly progressive liver failure, in the absence of hepatomegaly, secondary to systemic light chain–associated amyloidosis associated with multiple myeloma. Wolters Kluwer 2020-12-04 /pmc/articles/PMC8483873/ /pubmed/34604435 http://dx.doi.org/10.14309/crj.0000000000000479 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Kim, Hyun Jae
Tomaszewski, Marcel
Lam, Eric C.
Xiong, Wei
Moosavi, Sarvee
Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title_full Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title_fullStr Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title_full_unstemmed Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title_short Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
title_sort amyloidosis: a rare cause of severe cholestasis and acute liver failure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483873/
https://www.ncbi.nlm.nih.gov/pubmed/34604435
http://dx.doi.org/10.14309/crj.0000000000000479
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AT xiongwei amyloidosisararecauseofseverecholestasisandacuteliverfailure
AT moosavisarvee amyloidosisararecauseofseverecholestasisandacuteliverfailure

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