Cargando…

Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients

Cluster of differentiation 5 antigen-like (CD5L), derived from alveolar epithelial cells partly, is a secreted protein. It is shown that CD5L is associated with lung inflammation and systemic inflammatory diseases, but the relationship between CD5L and trauma-related acute lung parenchymal injury (P...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Qian, Lai, Xiaofei, Yang, Liping, Yang, Huiqing, Luo, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483880/
https://www.ncbi.nlm.nih.gov/pubmed/34596119
http://dx.doi.org/10.1097/MD.0000000000027219
_version_ 1784577208893833216
author Cheng, Qian
Lai, Xiaofei
Yang, Liping
Yang, Huiqing
Luo, Yan
author_facet Cheng, Qian
Lai, Xiaofei
Yang, Liping
Yang, Huiqing
Luo, Yan
author_sort Cheng, Qian
collection PubMed
description Cluster of differentiation 5 antigen-like (CD5L), derived from alveolar epithelial cells partly, is a secreted protein. It is shown that CD5L is associated with lung inflammation and systemic inflammatory diseases, but the relationship between CD5L and trauma-related acute lung parenchymal injury (PLI), acute lung injury or acute respiratory distress syndrome (ARDS) is unclear. This study aims to explore the value of serum CD5L levels in predicting trauma-associated PLI/ARDS and its potential clinical significance. This is a prospective observational study, and a total of 127 trauma patients were recruited from the emergency department (ED), and among them, 81 suffered from PLI/ARDS within 24 hours after trauma, and 46 suffered from trauma without PLI/ARDS. Fifty healthy subjects from the medical examination center were also recruited as controls for comparison. The serum CD5L level was measured within 24 hours of admission. The receiver operating characteristic analysis and logistic regression analysis were used to identify the correlation between high CD5L and trauma associated-PLI/ARDS within 24 hours following trauma. The trauma associated-PLI/ARDS subjects showed a significantly higher level of serum CD5L on emergency department admission within 24 hours after trauma compared with its level in non-trauma associated-PLI/ARDS subjects and healthy subjects. The initial CD5L concentration higher than 150.3 ng/mL was identified as indicating a high risk of PLI/ARDS within 24 hours following trauma (95% confidence interval: 0.674–0.878; P < .001). Moreover, CD5L was an independent risk factor for trauma associated-PLI/ARDS within 24 hours following trauma. CD5L could predict PLI/ARDS within 24 hours following trauma.
format Online
Article
Text
id pubmed-8483880
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-84838802021-10-04 Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients Cheng, Qian Lai, Xiaofei Yang, Liping Yang, Huiqing Luo, Yan Medicine (Baltimore) 3900 Cluster of differentiation 5 antigen-like (CD5L), derived from alveolar epithelial cells partly, is a secreted protein. It is shown that CD5L is associated with lung inflammation and systemic inflammatory diseases, but the relationship between CD5L and trauma-related acute lung parenchymal injury (PLI), acute lung injury or acute respiratory distress syndrome (ARDS) is unclear. This study aims to explore the value of serum CD5L levels in predicting trauma-associated PLI/ARDS and its potential clinical significance. This is a prospective observational study, and a total of 127 trauma patients were recruited from the emergency department (ED), and among them, 81 suffered from PLI/ARDS within 24 hours after trauma, and 46 suffered from trauma without PLI/ARDS. Fifty healthy subjects from the medical examination center were also recruited as controls for comparison. The serum CD5L level was measured within 24 hours of admission. The receiver operating characteristic analysis and logistic regression analysis were used to identify the correlation between high CD5L and trauma associated-PLI/ARDS within 24 hours following trauma. The trauma associated-PLI/ARDS subjects showed a significantly higher level of serum CD5L on emergency department admission within 24 hours after trauma compared with its level in non-trauma associated-PLI/ARDS subjects and healthy subjects. The initial CD5L concentration higher than 150.3 ng/mL was identified as indicating a high risk of PLI/ARDS within 24 hours following trauma (95% confidence interval: 0.674–0.878; P < .001). Moreover, CD5L was an independent risk factor for trauma associated-PLI/ARDS within 24 hours following trauma. CD5L could predict PLI/ARDS within 24 hours following trauma. Lippincott Williams & Wilkins 2021-10-01 /pmc/articles/PMC8483880/ /pubmed/34596119 http://dx.doi.org/10.1097/MD.0000000000027219 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 3900
Cheng, Qian
Lai, Xiaofei
Yang, Liping
Yang, Huiqing
Luo, Yan
Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title_full Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title_fullStr Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title_full_unstemmed Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title_short Serum CD5L predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
title_sort serum cd5l predicts acute lung parenchymal injury and acute respiratory distress syndrome in trauma patients
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483880/
https://www.ncbi.nlm.nih.gov/pubmed/34596119
http://dx.doi.org/10.1097/MD.0000000000027219
work_keys_str_mv AT chengqian serumcd5lpredictsacutelungparenchymalinjuryandacuterespiratorydistresssyndromeintraumapatients
AT laixiaofei serumcd5lpredictsacutelungparenchymalinjuryandacuterespiratorydistresssyndromeintraumapatients
AT yangliping serumcd5lpredictsacutelungparenchymalinjuryandacuterespiratorydistresssyndromeintraumapatients
AT yanghuiqing serumcd5lpredictsacutelungparenchymalinjuryandacuterespiratorydistresssyndromeintraumapatients
AT luoyan serumcd5lpredictsacutelungparenchymalinjuryandacuterespiratorydistresssyndromeintraumapatients