SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France

SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the...

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Autores principales: Roquebert, Benedicte, Haim-Boukobza, Stéphanie, Trombert-Paolantoni, Sabine, Lecorche, Emmanuel, Verdurme, Laura, Foulongne, Vincent, Burrel, Sonia, Alizon, Samuel, Sofonea, Mircea T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484004/
https://www.ncbi.nlm.nih.gov/pubmed/34601145
http://dx.doi.org/10.1016/j.ijid.2021.09.076
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author Roquebert, Benedicte
Haim-Boukobza, Stéphanie
Trombert-Paolantoni, Sabine
Lecorche, Emmanuel
Verdurme, Laura
Foulongne, Vincent
Burrel, Sonia
Alizon, Samuel
Sofonea, Mircea T.
author_facet Roquebert, Benedicte
Haim-Boukobza, Stéphanie
Trombert-Paolantoni, Sabine
Lecorche, Emmanuel
Verdurme, Laura
Foulongne, Vincent
Burrel, Sonia
Alizon, Samuel
Sofonea, Mircea T.
author_sort Roquebert, Benedicte
collection PubMed
description SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values.
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spelling pubmed-84840042021-10-01 SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France Roquebert, Benedicte Haim-Boukobza, Stéphanie Trombert-Paolantoni, Sabine Lecorche, Emmanuel Verdurme, Laura Foulongne, Vincent Burrel, Sonia Alizon, Samuel Sofonea, Mircea T. Int J Infect Dis Short Communication SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-12 2021-10-01 /pmc/articles/PMC8484004/ /pubmed/34601145 http://dx.doi.org/10.1016/j.ijid.2021.09.076 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Roquebert, Benedicte
Haim-Boukobza, Stéphanie
Trombert-Paolantoni, Sabine
Lecorche, Emmanuel
Verdurme, Laura
Foulongne, Vincent
Burrel, Sonia
Alizon, Samuel
Sofonea, Mircea T.
SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title_full SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title_fullStr SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title_full_unstemmed SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title_short SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France
title_sort sars-cov-2 variants of concern are associated with lower rt-pcr amplification cycles between january and march 2021 in france
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484004/
https://www.ncbi.nlm.nih.gov/pubmed/34601145
http://dx.doi.org/10.1016/j.ijid.2021.09.076
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