Cargando…

Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study

Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhanc...

Descripción completa

Detalles Bibliográficos
Autores principales: TERAHARA, Masaki, NAKAMURA, Yoshitaka, TSUBOI, Misato, JINNO, Shinji, TSUKAHARA, Takamitsu, MIYAKE, Takao, SHIMOJO, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484005/
https://www.ncbi.nlm.nih.gov/pubmed/34631331
http://dx.doi.org/10.12938/bmfh.2021-018
_version_ 1784577234394152960
author TERAHARA, Masaki
NAKAMURA, Yoshitaka
TSUBOI, Misato
JINNO, Shinji
TSUKAHARA, Takamitsu
MIYAKE, Takao
SHIMOJO, Naoki
author_facet TERAHARA, Masaki
NAKAMURA, Yoshitaka
TSUBOI, Misato
JINNO, Shinji
TSUKAHARA, Takamitsu
MIYAKE, Takao
SHIMOJO, Naoki
author_sort TERAHARA, Masaki
collection PubMed
description Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age. Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n=45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n=49) at four weeks of age (p=0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake.
format Online
Article
Text
id pubmed-8484005
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMFH Press
record_format MEDLINE/PubMed
spelling pubmed-84840052021-10-08 Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study TERAHARA, Masaki NAKAMURA, Yoshitaka TSUBOI, Misato JINNO, Shinji TSUKAHARA, Takamitsu MIYAKE, Takao SHIMOJO, Naoki Biosci Microbiota Food Health Full Paper Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age. Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n=45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n=49) at four weeks of age (p=0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake. BMFH Press 2021-08-10 2021 /pmc/articles/PMC8484005/ /pubmed/34631331 http://dx.doi.org/10.12938/bmfh.2021-018 Text en ©2021 BMFH Press https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Full Paper
TERAHARA, Masaki
NAKAMURA, Yoshitaka
TSUBOI, Misato
JINNO, Shinji
TSUKAHARA, Takamitsu
MIYAKE, Takao
SHIMOJO, Naoki
Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title_full Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title_fullStr Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title_full_unstemmed Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title_short Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
title_sort effects of the intake of non-live bifidobacterium bifidum on the faecal iga of full-term infants: a double-blind, randomised, placebo-controlled study
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484005/
https://www.ncbi.nlm.nih.gov/pubmed/34631331
http://dx.doi.org/10.12938/bmfh.2021-018
work_keys_str_mv AT teraharamasaki effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT nakamurayoshitaka effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT tsuboimisato effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT jinnoshinji effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT tsukaharatakamitsu effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT miyaketakao effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy
AT shimojonaoki effectsoftheintakeofnonlivebifidobacteriumbifidumonthefaecaligaoffullterminfantsadoubleblindrandomisedplacebocontrolledstudy