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Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study
Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhanc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMFH Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484005/ https://www.ncbi.nlm.nih.gov/pubmed/34631331 http://dx.doi.org/10.12938/bmfh.2021-018 |
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author | TERAHARA, Masaki NAKAMURA, Yoshitaka TSUBOI, Misato JINNO, Shinji TSUKAHARA, Takamitsu MIYAKE, Takao SHIMOJO, Naoki |
author_facet | TERAHARA, Masaki NAKAMURA, Yoshitaka TSUBOI, Misato JINNO, Shinji TSUKAHARA, Takamitsu MIYAKE, Takao SHIMOJO, Naoki |
author_sort | TERAHARA, Masaki |
collection | PubMed |
description | Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age. Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n=45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n=49) at four weeks of age (p=0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake. |
format | Online Article Text |
id | pubmed-8484005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMFH Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84840052021-10-08 Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study TERAHARA, Masaki NAKAMURA, Yoshitaka TSUBOI, Misato JINNO, Shinji TSUKAHARA, Takamitsu MIYAKE, Takao SHIMOJO, Naoki Biosci Microbiota Food Health Full Paper Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age. Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n=45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n=49) at four weeks of age (p=0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake. BMFH Press 2021-08-10 2021 /pmc/articles/PMC8484005/ /pubmed/34631331 http://dx.doi.org/10.12938/bmfh.2021-018 Text en ©2021 BMFH Press https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Full Paper TERAHARA, Masaki NAKAMURA, Yoshitaka TSUBOI, Misato JINNO, Shinji TSUKAHARA, Takamitsu MIYAKE, Takao SHIMOJO, Naoki Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title | Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title_full | Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title_fullStr | Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title_full_unstemmed | Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title_short | Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study |
title_sort | effects of the intake of non-live bifidobacterium bifidum on the faecal iga of full-term infants: a double-blind, randomised, placebo-controlled study |
topic | Full Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484005/ https://www.ncbi.nlm.nih.gov/pubmed/34631331 http://dx.doi.org/10.12938/bmfh.2021-018 |
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