A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein (FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. Here we have developed an FXS human forebrain organoid model and observed the loss of FMRP led to dysregulated neurogenesis, neur...

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Detalles Bibliográficos
Autores principales: Kang, Yunhee, Zhou, Ying, Li, Yujing, Han, Yanfei, Xu, Jie, Niu, Weibo, Li, Ziyi, Liu, Shiying, Feng, Hao, Huang, Wen, Duan, Ranhui, Xu, Tianmin, Raj, Nisha, Zhang, Feiran, Dou, Juan, Xu, Chongchong, Wu, Hao, Bassell, Gary J, Warren, Stephen T, Allen, Emily G, Jin, Peng, Wen, Zhexing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484073/
https://www.ncbi.nlm.nih.gov/pubmed/34413513
http://dx.doi.org/10.1038/s41593-021-00913-6

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