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Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project
Osteoporosis is an important global health problem resulting in fragility fractures. The vertebrae are the commonest site of fracture resulting in extreme illness burden, and having the highest associated mortality. International studies show that vertebral fractures (VF) increase in prevalence with...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484104/ https://www.ncbi.nlm.nih.gov/pubmed/34085087 http://dx.doi.org/10.1007/s00223-021-00868-7 |
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author | Carey, John J Yang, Lan Erjiang, E. Wang, Tingyan Gorham, Kelly Egan, Rebecca Brennan, Attracta Dempsey, Mary Armstrong, Catherine Heaney, Fiona McCabe, Eva Yu, Ming |
author_facet | Carey, John J Yang, Lan Erjiang, E. Wang, Tingyan Gorham, Kelly Egan, Rebecca Brennan, Attracta Dempsey, Mary Armstrong, Catherine Heaney, Fiona McCabe, Eva Yu, Ming |
author_sort | Carey, John J |
collection | PubMed |
description | Osteoporosis is an important global health problem resulting in fragility fractures. The vertebrae are the commonest site of fracture resulting in extreme illness burden, and having the highest associated mortality. International studies show that vertebral fractures (VF) increase in prevalence with age, similarly in men and women, but differ across different regions of the world. Ireland has one of the highest rates of hip fracture in the world but data on vertebral fractures are limited. In this study we examined the prevalence of VF and associated major risk factors, using a sample of subjects who underwent vertebral fracture assessment (VFA) performed on 2 dual-energy X-ray absorptiometry (DXA) machines. A total of 1296 subjects aged 40 years and older had a valid VFA report and DXA information available, including 254 men and 1042 women. Subjects had a mean age of 70 years, 805 (62%) had prior fractures, mean spine T-score was − 1.4 and mean total hip T-scores was − 1.2, while mean FRAX scores were 15.4% and 4.8% for major osteoporotic fracture and hip fracture, respectively. Although 95 (7%) had a known VF prior to scanning, 283 (22%) patients had at least 1 VF on their scan: 161 had 1, 61 had 2, and 61 had 3 or more. The prevalence of VF increased with age from 11.5% in those aged 40–49 years to > 33% among those aged ≥ 80 years. Both men and women with VF had significantly lower BMD at each measured site, and significantly higher FRAX scores, P < 0.01. These data suggest VF are common in high risk populations, particularly older men and women with low BMD, previous fractures, and at high risk of fracture. Urgent attention is needed to examine effective ways to identify those at risk and to reduce the burden of VF. |
format | Online Article Text |
id | pubmed-8484104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-84841042021-10-08 Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project Carey, John J Yang, Lan Erjiang, E. Wang, Tingyan Gorham, Kelly Egan, Rebecca Brennan, Attracta Dempsey, Mary Armstrong, Catherine Heaney, Fiona McCabe, Eva Yu, Ming Calcif Tissue Int Original Research Osteoporosis is an important global health problem resulting in fragility fractures. The vertebrae are the commonest site of fracture resulting in extreme illness burden, and having the highest associated mortality. International studies show that vertebral fractures (VF) increase in prevalence with age, similarly in men and women, but differ across different regions of the world. Ireland has one of the highest rates of hip fracture in the world but data on vertebral fractures are limited. In this study we examined the prevalence of VF and associated major risk factors, using a sample of subjects who underwent vertebral fracture assessment (VFA) performed on 2 dual-energy X-ray absorptiometry (DXA) machines. A total of 1296 subjects aged 40 years and older had a valid VFA report and DXA information available, including 254 men and 1042 women. Subjects had a mean age of 70 years, 805 (62%) had prior fractures, mean spine T-score was − 1.4 and mean total hip T-scores was − 1.2, while mean FRAX scores were 15.4% and 4.8% for major osteoporotic fracture and hip fracture, respectively. Although 95 (7%) had a known VF prior to scanning, 283 (22%) patients had at least 1 VF on their scan: 161 had 1, 61 had 2, and 61 had 3 or more. The prevalence of VF increased with age from 11.5% in those aged 40–49 years to > 33% among those aged ≥ 80 years. Both men and women with VF had significantly lower BMD at each measured site, and significantly higher FRAX scores, P < 0.01. These data suggest VF are common in high risk populations, particularly older men and women with low BMD, previous fractures, and at high risk of fracture. Urgent attention is needed to examine effective ways to identify those at risk and to reduce the burden of VF. Springer US 2021-06-03 2021 /pmc/articles/PMC8484104/ /pubmed/34085087 http://dx.doi.org/10.1007/s00223-021-00868-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Carey, John J Yang, Lan Erjiang, E. Wang, Tingyan Gorham, Kelly Egan, Rebecca Brennan, Attracta Dempsey, Mary Armstrong, Catherine Heaney, Fiona McCabe, Eva Yu, Ming Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title | Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title_full | Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title_fullStr | Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title_full_unstemmed | Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title_short | Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project |
title_sort | vertebral fractures in ireland: a sub-analysis of the dxa hip project |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484104/ https://www.ncbi.nlm.nih.gov/pubmed/34085087 http://dx.doi.org/10.1007/s00223-021-00868-7 |
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