A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario...

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Autores principales: Wang, Guohao, Xie, Lisi, Li, Bei, Sang, Wei, Yan, Jie, Li, Jie, Tian, Hao, Li, Wenxi, Zhang, Zhan, Tian, Ye, Dai, Yunlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484261/
https://www.ncbi.nlm.nih.gov/pubmed/34593794
http://dx.doi.org/10.1038/s41467-021-25990-w
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author Wang, Guohao
Xie, Lisi
Li, Bei
Sang, Wei
Yan, Jie
Li, Jie
Tian, Hao
Li, Wenxi
Zhang, Zhan
Tian, Ye
Dai, Yunlu
author_facet Wang, Guohao
Xie, Lisi
Li, Bei
Sang, Wei
Yan, Jie
Li, Jie
Tian, Hao
Li, Wenxi
Zhang, Zhan
Tian, Ye
Dai, Yunlu
author_sort Wang, Guohao
collection PubMed
description In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario, suppressing the secretion of tumor-derived exosomes may aid therapy. Here, we develop an assembly of exosome inhibitor (GW4869) and ferroptosis inducer (Fe(3+)) via amphiphilic hyaluronic acid. Cooperation between the two active components in the constructed nanounit induces an anti-tumor immunoresponse to B16F10 melanoma cells and stimulates cytotoxic T lymphocytes and immunological memory. The nanounit enhances the response to PD-L1 checkpoint blockade and may represent a therapeutic strategy for enhancing the response to this therapy.
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spelling pubmed-84842612021-10-22 A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis Wang, Guohao Xie, Lisi Li, Bei Sang, Wei Yan, Jie Li, Jie Tian, Hao Li, Wenxi Zhang, Zhan Tian, Ye Dai, Yunlu Nat Commun Article In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario, suppressing the secretion of tumor-derived exosomes may aid therapy. Here, we develop an assembly of exosome inhibitor (GW4869) and ferroptosis inducer (Fe(3+)) via amphiphilic hyaluronic acid. Cooperation between the two active components in the constructed nanounit induces an anti-tumor immunoresponse to B16F10 melanoma cells and stimulates cytotoxic T lymphocytes and immunological memory. The nanounit enhances the response to PD-L1 checkpoint blockade and may represent a therapeutic strategy for enhancing the response to this therapy. Nature Publishing Group UK 2021-09-30 /pmc/articles/PMC8484261/ /pubmed/34593794 http://dx.doi.org/10.1038/s41467-021-25990-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Guohao
Xie, Lisi
Li, Bei
Sang, Wei
Yan, Jie
Li, Jie
Tian, Hao
Li, Wenxi
Zhang, Zhan
Tian, Ye
Dai, Yunlu
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_fullStr A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full_unstemmed A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_short A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_sort nanounit strategy reverses immune suppression of exosomal pd-l1 and is associated with enhanced ferroptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484261/
https://www.ncbi.nlm.nih.gov/pubmed/34593794
http://dx.doi.org/10.1038/s41467-021-25990-w
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