BAP1 methylation: a prognostic marker of uveal melanoma metastasis

Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Bakhoum, Mathieu F., Curtis, Ellis J., Goldbaum, Michael H., Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484429/
https://www.ncbi.nlm.nih.gov/pubmed/34593944
http://dx.doi.org/10.1038/s41698-021-00226-8
Descripción
Sumario:Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.

Ejemplares similares