BAP1 methylation: a prognostic marker of uveal melanoma metastasis

Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. H...

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Autores principales: Bakhoum, Mathieu F., Curtis, Ellis J., Goldbaum, Michael H., Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484429/
https://www.ncbi.nlm.nih.gov/pubmed/34593944
http://dx.doi.org/10.1038/s41698-021-00226-8
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author Bakhoum, Mathieu F.
Curtis, Ellis J.
Goldbaum, Michael H.
Mischel, Paul S.
author_facet Bakhoum, Mathieu F.
Curtis, Ellis J.
Goldbaum, Michael H.
Mischel, Paul S.
author_sort Bakhoum, Mathieu F.
collection PubMed
description Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.
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spelling pubmed-84844292021-10-12 BAP1 methylation: a prognostic marker of uveal melanoma metastasis Bakhoum, Mathieu F. Curtis, Ellis J. Goldbaum, Michael H. Mischel, Paul S. NPJ Precis Oncol Brief Communication Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients. Nature Publishing Group UK 2021-09-30 /pmc/articles/PMC8484429/ /pubmed/34593944 http://dx.doi.org/10.1038/s41698-021-00226-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Bakhoum, Mathieu F.
Curtis, Ellis J.
Goldbaum, Michael H.
Mischel, Paul S.
BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_full BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_fullStr BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_full_unstemmed BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_short BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_sort bap1 methylation: a prognostic marker of uveal melanoma metastasis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484429/
https://www.ncbi.nlm.nih.gov/pubmed/34593944
http://dx.doi.org/10.1038/s41698-021-00226-8
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