Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA(2) homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle damage and are therefore named ‘myotoxins’. Single intact and skinned (devoid of...

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Detalles Bibliográficos
Autores principales: López-Dávila, Alfredo Jesús, Weber, Natalie, Kraft, Theresia, Matinmehr, Faramarz, Arias-Hidalgo, Mariela, Fernández, Julián, Lomonte, Bruno, Gutiérrez, José María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484475/
https://www.ncbi.nlm.nih.gov/pubmed/34593882
http://dx.doi.org/10.1038/s41598-021-98594-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484475/
https://www.ncbi.nlm.nih.gov/pubmed/34593882
http://dx.doi.org/10.1038/s41598-021-98594-5

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