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Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice
In humans, loss-of-function mutations in the UBE3A gene lead to the neurodevelopmental disorder Angelman syndrome (AS). AS patients have severe impairments in speech, learning and memory, and motor coordination, for which there is currently no treatment. In addition, UBE3A is duplicated in > 1–2%...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484563/ https://www.ncbi.nlm.nih.gov/pubmed/34593829 http://dx.doi.org/10.1038/s41598-021-97898-w |