Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Warren, Travis K., Kane, Christopher D., Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Steffens, Jesse, Gomba, Laura, Weidner, Jessica M., Norris, Sarah, Zeng, Xiankun, Bannister, Roy, Cihlar, Tomas, Bavari, Sina, Porter, Danielle P., Iversen, Patrick L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484580/
https://www.ncbi.nlm.nih.gov/pubmed/34593911
http://dx.doi.org/10.1038/s41598-021-98971-0
_version_ 1784577348518019072
author Warren, Travis K.
Kane, Christopher D.
Wells, Jay
Stuthman, Kelly S.
Van Tongeren, Sean A.
Garza, Nicole L.
Donnelly, Ginger
Steffens, Jesse
Gomba, Laura
Weidner, Jessica M.
Norris, Sarah
Zeng, Xiankun
Bannister, Roy
Cihlar, Tomas
Bavari, Sina
Porter, Danielle P.
Iversen, Patrick L.
author_facet Warren, Travis K.
Kane, Christopher D.
Wells, Jay
Stuthman, Kelly S.
Van Tongeren, Sean A.
Garza, Nicole L.
Donnelly, Ginger
Steffens, Jesse
Gomba, Laura
Weidner, Jessica M.
Norris, Sarah
Zeng, Xiankun
Bannister, Roy
Cihlar, Tomas
Bavari, Sina
Porter, Danielle P.
Iversen, Patrick L.
author_sort Warren, Travis K.
collection PubMed
description Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease.
format Online
Article
Text
id pubmed-8484580
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-84845802021-10-04 Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus Warren, Travis K. Kane, Christopher D. Wells, Jay Stuthman, Kelly S. Van Tongeren, Sean A. Garza, Nicole L. Donnelly, Ginger Steffens, Jesse Gomba, Laura Weidner, Jessica M. Norris, Sarah Zeng, Xiankun Bannister, Roy Cihlar, Tomas Bavari, Sina Porter, Danielle P. Iversen, Patrick L. Sci Rep Article Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease. Nature Publishing Group UK 2021-09-30 /pmc/articles/PMC8484580/ /pubmed/34593911 http://dx.doi.org/10.1038/s41598-021-98971-0 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Warren, Travis K.
Kane, Christopher D.
Wells, Jay
Stuthman, Kelly S.
Van Tongeren, Sean A.
Garza, Nicole L.
Donnelly, Ginger
Steffens, Jesse
Gomba, Laura
Weidner, Jessica M.
Norris, Sarah
Zeng, Xiankun
Bannister, Roy
Cihlar, Tomas
Bavari, Sina
Porter, Danielle P.
Iversen, Patrick L.
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_full Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_fullStr Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_full_unstemmed Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_short Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
title_sort remdesivir is efficacious in rhesus monkeys exposed to aerosolized ebola virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484580/
https://www.ncbi.nlm.nih.gov/pubmed/34593911
http://dx.doi.org/10.1038/s41598-021-98971-0
work_keys_str_mv AT warrentravisk remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT kanechristopherd remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT wellsjay remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT stuthmankellys remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT vantongerenseana remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT garzanicolel remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT donnellyginger remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT steffensjesse remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT gombalaura remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT weidnerjessicam remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT norrissarah remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT zengxiankun remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT bannisterroy remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT cihlartomas remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT bavarisina remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT porterdaniellep remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus
AT iversenpatrickl remdesivirisefficaciousinrhesusmonkeysexposedtoaerosolizedebolavirus

Ejemplares similares