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WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers
CCNE1 amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al.(1) identify a combination therapy that is responsive to high CCNE1-copy number ovarian and endometrial cancers using PDX models.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484682/ https://www.ncbi.nlm.nih.gov/pubmed/34622238 http://dx.doi.org/10.1016/j.xcrm.2021.100402 |
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| author | Goehring, Liana Huang, Tony T. |
| author_facet | Goehring, Liana Huang, Tony T. |
| author_sort | Goehring, Liana |
| collection | PubMed |
| description | CCNE1 amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al.(1) identify a combination therapy that is responsive to high CCNE1-copy number ovarian and endometrial cancers using PDX models. |
| format | Online Article Text |
| id | pubmed-8484682 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84846822021-10-06 WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers Goehring, Liana Huang, Tony T. Cell Rep Med Preview CCNE1 amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al.(1) identify a combination therapy that is responsive to high CCNE1-copy number ovarian and endometrial cancers using PDX models. Elsevier 2021-09-23 /pmc/articles/PMC8484682/ /pubmed/34622238 http://dx.doi.org/10.1016/j.xcrm.2021.100402 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Goehring, Liana Huang, Tony T. WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title | WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title_full | WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title_fullStr | WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title_full_unstemmed | WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title_short | WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers |
| title_sort | wee1i-atri combination therapy: a promising low-dose treatment for ccne1-amplified gynecologic cancers |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484682/ https://www.ncbi.nlm.nih.gov/pubmed/34622238 http://dx.doi.org/10.1016/j.xcrm.2021.100402 |
| work_keys_str_mv | AT goehringliana wee1iatricombinationtherapyapromisinglowdosetreatmentforccne1amplifiedgynecologiccancers AT huangtonyt wee1iatricombinationtherapyapromisinglowdosetreatmentforccne1amplifiedgynecologiccancers |