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Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men
Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investigate the ro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484687/ https://www.ncbi.nlm.nih.gov/pubmed/34622233 http://dx.doi.org/10.1016/j.xcrm.2021.100396 |
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author | Trinh, Beckey Peletier, Merel Simonsen, Casper Plomgaard, Peter Karstoft, Kristian Klarlund Pedersen, Bente van Hall, Gerrit Ellingsgaard, Helga |
author_facet | Trinh, Beckey Peletier, Merel Simonsen, Casper Plomgaard, Peter Karstoft, Kristian Klarlund Pedersen, Bente van Hall, Gerrit Ellingsgaard, Helga |
author_sort | Trinh, Beckey |
collection | PubMed |
description | Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investigate the role of endogenous IL-6 in regulating systemic energy metabolism at rest and during exercise and recovery in lean and obese men using tracer dilution methodology. Tocilizumab reduces fatty acid appearance in the circulation under all conditions in lean and obese individuals, whereas lipolysis (the rate of glycerol appearance into the circulation) is mostly unaffected. The fact that fatty acid oxidation is unaffected by IL-6 receptor blockade suggests increased re-esterification of fatty acids. Glucose kinetics are unaffected. We find that blocking endogenous IL-6 signaling with tocilizumab impairs fat mobilization, which may contribute to expansion of adipose tissue mass and, thus, affect the health of individuals undergoing anti-IL-6 therapy (Clinicaltrials.gov: NCT03967691). |
format | Online Article Text |
id | pubmed-8484687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84846872021-10-06 Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men Trinh, Beckey Peletier, Merel Simonsen, Casper Plomgaard, Peter Karstoft, Kristian Klarlund Pedersen, Bente van Hall, Gerrit Ellingsgaard, Helga Cell Rep Med Article Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investigate the role of endogenous IL-6 in regulating systemic energy metabolism at rest and during exercise and recovery in lean and obese men using tracer dilution methodology. Tocilizumab reduces fatty acid appearance in the circulation under all conditions in lean and obese individuals, whereas lipolysis (the rate of glycerol appearance into the circulation) is mostly unaffected. The fact that fatty acid oxidation is unaffected by IL-6 receptor blockade suggests increased re-esterification of fatty acids. Glucose kinetics are unaffected. We find that blocking endogenous IL-6 signaling with tocilizumab impairs fat mobilization, which may contribute to expansion of adipose tissue mass and, thus, affect the health of individuals undergoing anti-IL-6 therapy (Clinicaltrials.gov: NCT03967691). Elsevier 2021-09-09 /pmc/articles/PMC8484687/ /pubmed/34622233 http://dx.doi.org/10.1016/j.xcrm.2021.100396 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Trinh, Beckey Peletier, Merel Simonsen, Casper Plomgaard, Peter Karstoft, Kristian Klarlund Pedersen, Bente van Hall, Gerrit Ellingsgaard, Helga Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title | Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title_full | Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title_fullStr | Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title_full_unstemmed | Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title_short | Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
title_sort | blocking endogenous il-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484687/ https://www.ncbi.nlm.nih.gov/pubmed/34622233 http://dx.doi.org/10.1016/j.xcrm.2021.100396 |
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