Cargando…

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investigate the ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trinh, Beckey, Peletier, Merel, Simonsen, Casper, Plomgaard, Peter, Karstoft, Kristian, Klarlund Pedersen, Bente, van Hall, Gerrit, Ellingsgaard, Helga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484687/ https://www.ncbi.nlm.nih.gov/pubmed/34622233 http://dx.doi.org/10.1016/j.xcrm.2021.100396

Ejemplares similares

The Acute Effects of Low-Dose TNF-α on Glucose Metabolism and β-Cell Function in Humans
por: Ibfelt, Tobias, et al.
Publicado: (2014)

The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males: A Randomized, Crossover, Counterbalanced Trial
por: Pilmark, Nanna Skytt, et al.
Publicado: (2021)

Exercise and the dipeptidyl‐peptidase IV inhibitor sitagliptin do not improve beta‐cell function and glucose homeostasis in long‐lasting type 1 diabetes—A randomised open‐label study
por: Seelig, Eleonora, et al.
Publicado: (2019)

Endurance Training Improves GLP-1 Sensitivity and Glucose Tolerance in Overweight Women
por: Åkerström, Thorbjörn, et al.
Publicado: (2022)

IL-6 Receptor Blockade Increases Circulating Adiponectin Levels in People with Obesity: An Explanatory Analysis
por: Wueest, Stephan, et al.
Publicado: (2021)

The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial
por: Christensen, Regitse Højgaard, et al.
Publicado: (2018)

The immediate effects of a single bout of aerobic exercise on oral glucose tolerance across the glucose tolerance continuum
por: Knudsen, Sine H., et al.
Publicado: (2014)

Is Lean Management implementable in a department of radiology?
por: Karstoft, Jens, et al.
Publicado: (2011)

Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
por: Lehrskov, Louise Lang, et al.
Publicado: (2019)

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
por: Hansen, Jakob Schiøler, et al.
Publicado: (2015)

Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial
por: Jønck, Simon, et al.
Publicado: (2023)

Effect of aerobic exercise training on the fat fraction of the liver in persons with chronic hepatitis B and hepatic steatosis: Trial protocol for a randomized controlled intervention trial— The FitLiver study
por: Jespersen, Sofie, et al.
Publicado: (2023)

The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia
por: Andreasen, Anne Sofie, et al.
Publicado: (2009)

Criterion validity and reliability of a smartphone delivered sub-maximal fitness test for people with type 2 diabetes
por: Brinkløv, Cecilie Fau, et al.
Publicado: (2016)

Exercise as a Mean to Control Low-Grade Systemic Inflammation
por: Mathur, Neha, et al.
Publicado: (2008)

The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
por: Lyngbaek, Mark P. P., et al.
Publicado: (2021)

Effect of ecological momentary assessment, goal-setting and personalized phone-calls on adherence to interval walking training using the InterWalk application among patients with type 2 diabetes—A pilot randomized controlled trial
por: Valentiner, Laura Staun, et al.
Publicado: (2019)

Muscle-Organ Crosstalk: Focus on Immunometabolism
por: Bay, Marie Lund, et al.
Publicado: (2020)

Development of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: Smoking, Inflammation, or Simply Disuse?
por: Iepsen, Ulrik Winning, et al.
Publicado: (2020)

Blocking barrier and leaning hill
por: Kim, Chang-Ju
Publicado: (2018)

Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial
por: Legaard, Grit E., et al.
Publicado: (2023)

Long-term effect of smartphone-delivered Interval Walking Training on physical activity in patients with type 2 diabetes: protocol for a parallel group single-blinded randomised controlled trial
por: Valentiner, Laura Staun, et al.
Publicado: (2017)

Muscle–Organ Crosstalk: The Emerging Roles of Myokines
por: Severinsen, Mai Charlotte Krogh, et al.
Publicado: (2020)

Calprotectin — A Novel Marker of Obesity
por: Mortensen, Ole Hartvig, et al.
Publicado: (2009)

IAU Symposium 241 : Stellar Populations As Building Blocks Of Galaxies
por: Peletier, R F, et al.
Publicado: (2006)

GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance
por: Biensø, Rasmus S., et al.
Publicado: (2012)

Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
por: Solomon, Thomas P.J., et al.
Publicado: (2022)

Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
por: Asmar, Meena, et al.
Publicado: (2010)

Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes
por: Karstoft, Kristian, et al.
Publicado: (2017)

Insulin Modulation of Magnetoencephalographic Resting State Dynamics in Lean and Obese Subjects
por: Stingl, Krunoslav T., et al.
Publicado: (2010)

The Effects of a Lifestyle Intervention Supported by the InterWalk Smartphone App on Increasing Physical Activity Among Persons With Type 2 Diabetes: Parallel-Group, Randomized Trial
por: Thorsen, Ida Kær, et al.
Publicado: (2022)

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
por: Davegårdh, Cajsa, et al.
Publicado: (2019)

Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma
por: Trinh, Beckey, et al.
Publicado: (2019)

The Effects of Free-Living Interval-Walking Training on Glycemic Control, Body Composition, and Physical Fitness in Type 2 Diabetic Patients: A randomized, controlled trial
por: Karstoft, Kristian, et al.
Publicado: (2013)

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
por: Klein, Anders B., et al.
Publicado: (2021)

Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6
por: Scheele, Camilla, et al.
Publicado: (2012)

Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism—Role of HIV lipodystrophy
por: Lindegaard, Birgitte, et al.
Publicado: (2018)

Correction: Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism—Role of HIV lipodystrophy
por: Lindegaard, Birgitte, et al.
Publicado: (2018)

Partial-Body Cryostimulation Increases Resting Energy Expenditure in Lean and Obese Women
por: De Nardi, Massimo, et al.
Publicado: (2021)

Exercise training to increase tumour natural killer‐cell infiltration in men with localised prostate cancer: a randomised controlled trial
por: Djurhuus, Sissal Sigmundsdóttir, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0o23s4ept304upf3ibq0ieqiqd