Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imag...

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Autores principales: Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., Morrison, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484690/
https://www.ncbi.nlm.nih.gov/pubmed/34622234
http://dx.doi.org/10.1016/j.xcrm.2021.100397
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author Ahmed, Basma A.
Ong, Frank J.
Barra, Nicole G.
Blondin, Denis P.
Gunn, Elizabeth
Oreskovich, Stephan M.
Szamosi, Jake C.
Syed, Saad A.
Hutchings, Emily K.
Konyer, Norman B.
Singh, Nina P.
Yabut, Julian M.
Desjardins, Eric M.
Anhê, Fernando F.
Foley, Kevin P.
Holloway, Alison C.
Noseworthy, Michael D.
Haman, Francois
Carpentier, Andre C.
Surette, Michael G.
Schertzer, Jonathan D.
Punthakee, Zubin
Steinberg, Gregory R.
Morrison, Katherine M.
author_facet Ahmed, Basma A.
Ong, Frank J.
Barra, Nicole G.
Blondin, Denis P.
Gunn, Elizabeth
Oreskovich, Stephan M.
Szamosi, Jake C.
Syed, Saad A.
Hutchings, Emily K.
Konyer, Norman B.
Singh, Nina P.
Yabut, Julian M.
Desjardins, Eric M.
Anhê, Fernando F.
Foley, Kevin P.
Holloway, Alison C.
Noseworthy, Michael D.
Haman, Francois
Carpentier, Andre C.
Surette, Michael G.
Schertzer, Jonathan D.
Punthakee, Zubin
Steinberg, Gregory R.
Morrison, Katherine M.
author_sort Ahmed, Basma A.
collection PubMed
description In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota.
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spelling pubmed-84846902021-10-06 Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota Ahmed, Basma A. Ong, Frank J. Barra, Nicole G. Blondin, Denis P. Gunn, Elizabeth Oreskovich, Stephan M. Szamosi, Jake C. Syed, Saad A. Hutchings, Emily K. Konyer, Norman B. Singh, Nina P. Yabut, Julian M. Desjardins, Eric M. Anhê, Fernando F. Foley, Kevin P. Holloway, Alison C. Noseworthy, Michael D. Haman, Francois Carpentier, Andre C. Surette, Michael G. Schertzer, Jonathan D. Punthakee, Zubin Steinberg, Gregory R. Morrison, Katherine M. Cell Rep Med Article In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota. Elsevier 2021-09-14 /pmc/articles/PMC8484690/ /pubmed/34622234 http://dx.doi.org/10.1016/j.xcrm.2021.100397 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ahmed, Basma A.
Ong, Frank J.
Barra, Nicole G.
Blondin, Denis P.
Gunn, Elizabeth
Oreskovich, Stephan M.
Szamosi, Jake C.
Syed, Saad A.
Hutchings, Emily K.
Konyer, Norman B.
Singh, Nina P.
Yabut, Julian M.
Desjardins, Eric M.
Anhê, Fernando F.
Foley, Kevin P.
Holloway, Alison C.
Noseworthy, Michael D.
Haman, Francois
Carpentier, Andre C.
Surette, Michael G.
Schertzer, Jonathan D.
Punthakee, Zubin
Steinberg, Gregory R.
Morrison, Katherine M.
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title_full Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title_fullStr Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title_full_unstemmed Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title_short Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
title_sort lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484690/
https://www.ncbi.nlm.nih.gov/pubmed/34622234
http://dx.doi.org/10.1016/j.xcrm.2021.100397
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