Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis

Despite the high incidence of male infertility, only 30% of infertile men receive a causative diagnosis. To explore the regulatory mechanisms governing human germ cell function in normal and impaired spermatogenesis (crypto), we performed single-cell RNA sequencing (>30,000 cells). We find major...

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Detalles Bibliográficos
Autores principales: Di Persio, Sara, Tekath, Tobias, Siebert-Kuss, Lara Marie, Cremers, Jann-Frederik, Wistuba, Joachim, Li, Xiaolin, Meyer zu Hörste, Gerd, Drexler, Hannes C.A., Wyrwoll, Margot Julia, Tüttelmann, Frank, Dugas, Martin, Kliesch, Sabine, Schlatt, Stefan, Laurentino, Sandra, Neuhaus, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484693/
https://www.ncbi.nlm.nih.gov/pubmed/34622232
http://dx.doi.org/10.1016/j.xcrm.2021.100395

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