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Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T Lymphocytes

Metabolic and nutrient-sensing pathways play an important role in controlling the efficacy of effector T cells. Oxygen is a critical regulator of cellular metabolism. However, during immune responses T cells must function in oxygen-deficient, or hypoxic, environments. Here, we used high resolution m...

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Detalles Bibliográficos
Autores principales: Ross, Sarah H., Rollings, Christina M., Cantrell, Doreen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484760/
https://www.ncbi.nlm.nih.gov/pubmed/34603285
http://dx.doi.org/10.3389/fimmu.2021.712402