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IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria

Sepsis-induced cardiac injury (SIC) is one of the most common complications in the intensive care unit (ICU) with high morbidity and mortality. Mitochondrial dysfunction is one of the main reasons for SIC, and Interleukin-13 (IL-13) is a master regulator of mitochondria biogenesis. The aim of the pr...

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Autores principales: Guo, Xiaoyu, Hong, Ting, Zhang, Shen, Wei, Yazhong, Jin, Haizhen, Miao, Qing, Wang, Kai, Zhou, Miao, Wang, Chong, He, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484794/
https://www.ncbi.nlm.nih.gov/pubmed/34604237
http://dx.doi.org/10.3389/fcell.2021.736603
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author Guo, Xiaoyu
Hong, Ting
Zhang, Shen
Wei, Yazhong
Jin, Haizhen
Miao, Qing
Wang, Kai
Zhou, Miao
Wang, Chong
He, Bin
author_facet Guo, Xiaoyu
Hong, Ting
Zhang, Shen
Wei, Yazhong
Jin, Haizhen
Miao, Qing
Wang, Kai
Zhou, Miao
Wang, Chong
He, Bin
author_sort Guo, Xiaoyu
collection PubMed
description Sepsis-induced cardiac injury (SIC) is one of the most common complications in the intensive care unit (ICU) with high morbidity and mortality. Mitochondrial dysfunction is one of the main reasons for SIC, and Interleukin-13 (IL-13) is a master regulator of mitochondria biogenesis. The aim of the present study was to investigate the role of IL-13 in SIC and explore the underlying mechanism. It was found that reactive oxygen species (ROS) production and apoptosis were significantly increased in lipopolysaccharide (LPS)-stimulated primary cardiomyocytes, which was accompanied with obvious mitochondria dysfunction. The results of RNA-sequencing (RNA-seq), mitochondrial membrane potential, fatty acid uptake and oxidation rate suggested that treatment with IL-13 could restore the function and morphology of mitochondria, indicating that it played an important role in protecting septic cardiomyocytes. These findings demonstrated that IL-13 alleviated sepsis-induced cardiac inflammation and apoptosis by improving mitochondrial fatty acid uptake and oxidation, suggesting that IL-13 may prove to be a potential promising target for SIC treatment.
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spelling pubmed-84847942021-10-02 IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria Guo, Xiaoyu Hong, Ting Zhang, Shen Wei, Yazhong Jin, Haizhen Miao, Qing Wang, Kai Zhou, Miao Wang, Chong He, Bin Front Cell Dev Biol Cell and Developmental Biology Sepsis-induced cardiac injury (SIC) is one of the most common complications in the intensive care unit (ICU) with high morbidity and mortality. Mitochondrial dysfunction is one of the main reasons for SIC, and Interleukin-13 (IL-13) is a master regulator of mitochondria biogenesis. The aim of the present study was to investigate the role of IL-13 in SIC and explore the underlying mechanism. It was found that reactive oxygen species (ROS) production and apoptosis were significantly increased in lipopolysaccharide (LPS)-stimulated primary cardiomyocytes, which was accompanied with obvious mitochondria dysfunction. The results of RNA-sequencing (RNA-seq), mitochondrial membrane potential, fatty acid uptake and oxidation rate suggested that treatment with IL-13 could restore the function and morphology of mitochondria, indicating that it played an important role in protecting septic cardiomyocytes. These findings demonstrated that IL-13 alleviated sepsis-induced cardiac inflammation and apoptosis by improving mitochondrial fatty acid uptake and oxidation, suggesting that IL-13 may prove to be a potential promising target for SIC treatment. Frontiers Media S.A. 2021-09-17 /pmc/articles/PMC8484794/ /pubmed/34604237 http://dx.doi.org/10.3389/fcell.2021.736603 Text en Copyright © 2021 Guo, Hong, Zhang, Wei, Jin, Miao, Wang, Zhou, Wang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Guo, Xiaoyu
Hong, Ting
Zhang, Shen
Wei, Yazhong
Jin, Haizhen
Miao, Qing
Wang, Kai
Zhou, Miao
Wang, Chong
He, Bin
IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title_full IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title_fullStr IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title_full_unstemmed IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title_short IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria
title_sort il-13 alleviates cardiomyocyte apoptosis by improving fatty acid oxidation in mitochondria
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484794/
https://www.ncbi.nlm.nih.gov/pubmed/34604237
http://dx.doi.org/10.3389/fcell.2021.736603
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