IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant

IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 i...

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Autores principales: Bekele, Yonas, Sui, Yongjun, Berzofsky, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484798/
https://www.ncbi.nlm.nih.gov/pubmed/34603318
http://dx.doi.org/10.3389/fimmu.2021.737406
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author Bekele, Yonas
Sui, Yongjun
Berzofsky, Jay A.
author_facet Bekele, Yonas
Sui, Yongjun
Berzofsky, Jay A.
author_sort Bekele, Yonas
collection PubMed
description IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 in diagnosis, prognosis and treatment of COVID-19 patients. We also summarize a promising role of IL-7 as a vaccine adjuvant. It could potentially enhance the immune responses to vaccines especially against SARS-CoV-2 or other new vaccines.
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spelling pubmed-84847982021-10-02 IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant Bekele, Yonas Sui, Yongjun Berzofsky, Jay A. Front Immunol Immunology IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 in diagnosis, prognosis and treatment of COVID-19 patients. We also summarize a promising role of IL-7 as a vaccine adjuvant. It could potentially enhance the immune responses to vaccines especially against SARS-CoV-2 or other new vaccines. Frontiers Media S.A. 2021-09-17 /pmc/articles/PMC8484798/ /pubmed/34603318 http://dx.doi.org/10.3389/fimmu.2021.737406 Text en Copyright © 2021 Bekele, Sui and Berzofsky https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bekele, Yonas
Sui, Yongjun
Berzofsky, Jay A.
IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title_full IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title_fullStr IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title_full_unstemmed IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title_short IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
title_sort il-7 in sars-cov-2 infection and as a potential vaccine adjuvant
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484798/
https://www.ncbi.nlm.nih.gov/pubmed/34603318
http://dx.doi.org/10.3389/fimmu.2021.737406
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AT berzofskyjaya il7insarscov2infectionandasapotentialvaccineadjuvant

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