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Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion

The present retrospective study aimed to investigate the presence of truncal instability or titubation after the first seizure and second phase in patients with acute encephalopathy with reduced subcortical diffusion (AED). Of the 15 patients with AED who were admitted to our hospital for 3 years an...

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Autores principales: Kawano, Go, Yae, Yukako, Sakata, Kensuke, Yokochi, Takaoki, Imagi, Toru, Ohbu, Keizo, Matsuishi, Toyojiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484920/
https://www.ncbi.nlm.nih.gov/pubmed/34603191
http://dx.doi.org/10.3389/fneur.2021.740655
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author Kawano, Go
Yae, Yukako
Sakata, Kensuke
Yokochi, Takaoki
Imagi, Toru
Ohbu, Keizo
Matsuishi, Toyojiro
author_facet Kawano, Go
Yae, Yukako
Sakata, Kensuke
Yokochi, Takaoki
Imagi, Toru
Ohbu, Keizo
Matsuishi, Toyojiro
author_sort Kawano, Go
collection PubMed
description The present retrospective study aimed to investigate the presence of truncal instability or titubation after the first seizure and second phase in patients with acute encephalopathy with reduced subcortical diffusion (AED). Of the 15 patients with AED who were admitted to our hospital for 3 years and 2 months and had reached developmental milestones for sitting before disease onset, six experienced moderate-to-severe truncal instability while sitting after the first seizure. These patients had a significantly longer first seizure duration and significantly lower GCS scores 12–24 h after the first seizure, as well as significantly higher Tada score and Creatinine and blood glucose levels than those with mild or no truncal instability while in a seated position after the first seizure. Three 1-year-old children with bilateral frontal lobe lesions, particularly in the bilateral prefrontal lobe regions, demonstrated truncal titubation, which has not previously been reported as a clinical feature of AED. Tada score reported to be a predictor of AED prognosis and truncal instability in the sitting position after the first seizure may represent disease severity, but not the specific lesions. Conversely, truncal titubation might be suggestive of bilateral frontal lobe lesions, particularly in patients without severe instability. Further studies on the role of bilateral prefrontal lobe lesions to truncal titubation in patients with AED using more objective evaluation methods, such as stabilometry, are necessary.
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spelling pubmed-84849202021-10-02 Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion Kawano, Go Yae, Yukako Sakata, Kensuke Yokochi, Takaoki Imagi, Toru Ohbu, Keizo Matsuishi, Toyojiro Front Neurol Neurology The present retrospective study aimed to investigate the presence of truncal instability or titubation after the first seizure and second phase in patients with acute encephalopathy with reduced subcortical diffusion (AED). Of the 15 patients with AED who were admitted to our hospital for 3 years and 2 months and had reached developmental milestones for sitting before disease onset, six experienced moderate-to-severe truncal instability while sitting after the first seizure. These patients had a significantly longer first seizure duration and significantly lower GCS scores 12–24 h after the first seizure, as well as significantly higher Tada score and Creatinine and blood glucose levels than those with mild or no truncal instability while in a seated position after the first seizure. Three 1-year-old children with bilateral frontal lobe lesions, particularly in the bilateral prefrontal lobe regions, demonstrated truncal titubation, which has not previously been reported as a clinical feature of AED. Tada score reported to be a predictor of AED prognosis and truncal instability in the sitting position after the first seizure may represent disease severity, but not the specific lesions. Conversely, truncal titubation might be suggestive of bilateral frontal lobe lesions, particularly in patients without severe instability. Further studies on the role of bilateral prefrontal lobe lesions to truncal titubation in patients with AED using more objective evaluation methods, such as stabilometry, are necessary. Frontiers Media S.A. 2021-09-17 /pmc/articles/PMC8484920/ /pubmed/34603191 http://dx.doi.org/10.3389/fneur.2021.740655 Text en Copyright © 2021 Kawano, Yae, Sakata, Yokochi, Imagi, Ohbu and Matsuishi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kawano, Go
Yae, Yukako
Sakata, Kensuke
Yokochi, Takaoki
Imagi, Toru
Ohbu, Keizo
Matsuishi, Toyojiro
Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title_full Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title_fullStr Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title_full_unstemmed Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title_short Truncal Instability and Titubation in Patients With Acute Encephalopathy With Reduced Subcortical Diffusion
title_sort truncal instability and titubation in patients with acute encephalopathy with reduced subcortical diffusion
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484920/
https://www.ncbi.nlm.nih.gov/pubmed/34603191
http://dx.doi.org/10.3389/fneur.2021.740655
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