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Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients

Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep defici...

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Autores principales: Podder, Indrashis, Mondal, Himel, Kroumpouzos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484989/
https://www.ncbi.nlm.nih.gov/pubmed/34632036
http://dx.doi.org/10.1016/j.ijwd.2021.02.010
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author Podder, Indrashis
Mondal, Himel
Kroumpouzos, George
author_facet Podder, Indrashis
Mondal, Himel
Kroumpouzos, George
author_sort Podder, Indrashis
collection PubMed
description Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep deficit, which can lead to physical and mental disturbances (e.g., daytime somnolence and fatigue) and negative emotional states that profoundly affect quality of life. However, this aspect of NP is often overlooked by dermatologists. It is essential to assess sleep quality in such patients and adopt appropriate measures to arrest the problem at an early stage. We conducted an evidence-based literature review to highlight the pathogenetic mechanisms of NP, identify dermatologic etiologies, and explore methods that have been used to assess the quality of sleep. Furthermore, we performed a systematic review of studies on sleep disturbance relevant to NP in patients with dermatologic conditions. Finally, we discuss the evidence on treatment options for NP and indicate therapies that may target both NP and sleep disturbance.
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spelling pubmed-84849892021-10-07 Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients Podder, Indrashis Mondal, Himel Kroumpouzos, George Int J Womens Dermatol Review Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep deficit, which can lead to physical and mental disturbances (e.g., daytime somnolence and fatigue) and negative emotional states that profoundly affect quality of life. However, this aspect of NP is often overlooked by dermatologists. It is essential to assess sleep quality in such patients and adopt appropriate measures to arrest the problem at an early stage. We conducted an evidence-based literature review to highlight the pathogenetic mechanisms of NP, identify dermatologic etiologies, and explore methods that have been used to assess the quality of sleep. Furthermore, we performed a systematic review of studies on sleep disturbance relevant to NP in patients with dermatologic conditions. Finally, we discuss the evidence on treatment options for NP and indicate therapies that may target both NP and sleep disturbance. Elsevier 2021-03-03 /pmc/articles/PMC8484989/ /pubmed/34632036 http://dx.doi.org/10.1016/j.ijwd.2021.02.010 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Podder, Indrashis
Mondal, Himel
Kroumpouzos, George
Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title_full Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title_fullStr Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title_full_unstemmed Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title_short Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
title_sort nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484989/
https://www.ncbi.nlm.nih.gov/pubmed/34632036
http://dx.doi.org/10.1016/j.ijwd.2021.02.010
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