Using microbial metalo-aminopeptidases as targets in human infectious diseases

Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and pathogenesis. For another group, it is not clear i...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Bacerio, Jorge, Izquierdo, Maikel, Aguado, Mirtha Elisa, Varela, Ana C., González-Matos, Maikel, del Rivero, Maday Alonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485470/
https://www.ncbi.nlm.nih.gov/pubmed/34692819
http://dx.doi.org/10.15698/mic2021.10.761
_version_ 1784577543115898880
author González-Bacerio, Jorge
Izquierdo, Maikel
Aguado, Mirtha Elisa
Varela, Ana C.
González-Matos, Maikel
del Rivero, Maday Alonso
author_facet González-Bacerio, Jorge
Izquierdo, Maikel
Aguado, Mirtha Elisa
Varela, Ana C.
González-Matos, Maikel
del Rivero, Maday Alonso
author_sort González-Bacerio, Jorge
collection PubMed
description Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and pathogenesis. For another group, it is not clear if their enzymatic activity is involved in the critical functions that they mediate. But one aspect has been established: they display relevant roles in bacteria and protozoa that could be targeted for therapeutic purposes. This work aims to describe these biological functions for several microbial metalo-aminopeptidases.
format Online
Article
Text
id pubmed-8485470
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Shared Science Publishers OG
record_format MEDLINE/PubMed
spelling pubmed-84854702021-10-22 Using microbial metalo-aminopeptidases as targets in human infectious diseases González-Bacerio, Jorge Izquierdo, Maikel Aguado, Mirtha Elisa Varela, Ana C. González-Matos, Maikel del Rivero, Maday Alonso Microb Cell Review Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and pathogenesis. For another group, it is not clear if their enzymatic activity is involved in the critical functions that they mediate. But one aspect has been established: they display relevant roles in bacteria and protozoa that could be targeted for therapeutic purposes. This work aims to describe these biological functions for several microbial metalo-aminopeptidases. Shared Science Publishers OG 2021-08-09 /pmc/articles/PMC8485470/ /pubmed/34692819 http://dx.doi.org/10.15698/mic2021.10.761 Text en Copyright: © 2021 González-Bacerio et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Review
González-Bacerio, Jorge
Izquierdo, Maikel
Aguado, Mirtha Elisa
Varela, Ana C.
González-Matos, Maikel
del Rivero, Maday Alonso
Using microbial metalo-aminopeptidases as targets in human infectious diseases
title Using microbial metalo-aminopeptidases as targets in human infectious diseases
title_full Using microbial metalo-aminopeptidases as targets in human infectious diseases
title_fullStr Using microbial metalo-aminopeptidases as targets in human infectious diseases
title_full_unstemmed Using microbial metalo-aminopeptidases as targets in human infectious diseases
title_short Using microbial metalo-aminopeptidases as targets in human infectious diseases
title_sort using microbial metalo-aminopeptidases as targets in human infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485470/
https://www.ncbi.nlm.nih.gov/pubmed/34692819
http://dx.doi.org/10.15698/mic2021.10.761
work_keys_str_mv AT gonzalezbaceriojorge usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases
AT izquierdomaikel usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases
AT aguadomirthaelisa usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases
AT varelaanac usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases
AT gonzalezmatosmaikel usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases
AT delriveromadayalonso usingmicrobialmetaloaminopeptidasesastargetsinhumaninfectiousdiseases

Ejemplares similares