Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021

Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The ind...

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Detalles Bibliográficos
Autores principales: Mazur-Panasiuk, Natalia, Rabalski, Lukasz, Gromowski, Tomasz, Nowicki, Grzegorz, Kowalski, Michal, Wydmanski, Witold, Szulc, Piotr, Kosinski, Maciej, Gackowska, Karolina, Drweska-Matelska, Natalia, Grabowski, Jakub, Piotrowska-Mietelska, Anna, Szewczyk, Boguslaw, Bienkowska-Szewczyk, Krystyna, Swadzba, Jakub, Labaj, Pawel, Grzybek, Maciej, Pyrc, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485581/
https://www.ncbi.nlm.nih.gov/pubmed/34596017
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.39.2100902
Descripción
Sumario:Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study.

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