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Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021
Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The ind...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485581/ https://www.ncbi.nlm.nih.gov/pubmed/34596017 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.39.2100902 |
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| author | Mazur-Panasiuk, Natalia Rabalski, Lukasz Gromowski, Tomasz Nowicki, Grzegorz Kowalski, Michal Wydmanski, Witold Szulc, Piotr Kosinski, Maciej Gackowska, Karolina Drweska-Matelska, Natalia Grabowski, Jakub Piotrowska-Mietelska, Anna Szewczyk, Boguslaw Bienkowska-Szewczyk, Krystyna Swadzba, Jakub Labaj, Pawel Grzybek, Maciej Pyrc, Krzysztof |
| author_facet | Mazur-Panasiuk, Natalia Rabalski, Lukasz Gromowski, Tomasz Nowicki, Grzegorz Kowalski, Michal Wydmanski, Witold Szulc, Piotr Kosinski, Maciej Gackowska, Karolina Drweska-Matelska, Natalia Grabowski, Jakub Piotrowska-Mietelska, Anna Szewczyk, Boguslaw Bienkowska-Szewczyk, Krystyna Swadzba, Jakub Labaj, Pawel Grzybek, Maciej Pyrc, Krzysztof |
| author_sort | Mazur-Panasiuk, Natalia |
| collection | PubMed |
| description | Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study. |
| format | Online Article Text |
| id | pubmed-8485581 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84855812021-10-18 Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 Mazur-Panasiuk, Natalia Rabalski, Lukasz Gromowski, Tomasz Nowicki, Grzegorz Kowalski, Michal Wydmanski, Witold Szulc, Piotr Kosinski, Maciej Gackowska, Karolina Drweska-Matelska, Natalia Grabowski, Jakub Piotrowska-Mietelska, Anna Szewczyk, Boguslaw Bienkowska-Szewczyk, Krystyna Swadzba, Jakub Labaj, Pawel Grzybek, Maciej Pyrc, Krzysztof Euro Surveill Rapid Communication Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study. European Centre for Disease Prevention and Control (ECDC) 2021-09-30 /pmc/articles/PMC8485581/ /pubmed/34596017 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.39.2100902 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Mazur-Panasiuk, Natalia Rabalski, Lukasz Gromowski, Tomasz Nowicki, Grzegorz Kowalski, Michal Wydmanski, Witold Szulc, Piotr Kosinski, Maciej Gackowska, Karolina Drweska-Matelska, Natalia Grabowski, Jakub Piotrowska-Mietelska, Anna Szewczyk, Boguslaw Bienkowska-Szewczyk, Krystyna Swadzba, Jakub Labaj, Pawel Grzybek, Maciej Pyrc, Krzysztof Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title | Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title_full | Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title_fullStr | Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title_full_unstemmed | Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title_short | Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021 |
| title_sort | expansion of a sars-cov-2 delta variant with an 872 nt deletion encompassing orf7a, orf7b and orf8, poland, july to august 2021 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485581/ https://www.ncbi.nlm.nih.gov/pubmed/34596017 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.39.2100902 |
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