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Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the...

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Autores principales: Tizenberg, Boris N., Brenner, Lisa A., Lowry, Christopher A., Okusaga, Olaoluwa O., Benavides, David R., Hoisington, Andrew J., Benros, Michael E., Stiller, John W., Kessler, Ronald C., Postolache, Teodor T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485771/
https://www.ncbi.nlm.nih.gov/pubmed/34648081
http://dx.doi.org/10.1007/s11920-021-01275-3
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author Tizenberg, Boris N.
Brenner, Lisa A.
Lowry, Christopher A.
Okusaga, Olaoluwa O.
Benavides, David R.
Hoisington, Andrew J.
Benros, Michael E.
Stiller, John W.
Kessler, Ronald C.
Postolache, Teodor T.
author_facet Tizenberg, Boris N.
Brenner, Lisa A.
Lowry, Christopher A.
Okusaga, Olaoluwa O.
Benavides, David R.
Hoisington, Andrew J.
Benros, Michael E.
Stiller, John W.
Kessler, Ronald C.
Postolache, Teodor T.
author_sort Tizenberg, Boris N.
collection PubMed
description PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Most common psychiatric manifestations include delirium, mood disorders, anxiety disorders, and posttraumatic stress disorder. “Long-COVID” non-syndromal presentations include “brain-fogginess,” autonomic instability, fatigue, and insomnia. SUMMARY: SARS-CoV-2 infection can trigger prior vulnerabilities based on the priming of microglia and other cells, induced or perpetuated by aging and mental and physical illnesses. COVID-19 could further induce priming of neuroimmunological substrates leading to exacerbated immune response and autoimmunity targeting structures in the central nervous system (CNS), in response to minor immune activating environmental exposures, including stress, minor infections, allergens, pollutants, and traumatic brain injury.
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spelling pubmed-84857712021-10-04 Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 Tizenberg, Boris N. Brenner, Lisa A. Lowry, Christopher A. Okusaga, Olaoluwa O. Benavides, David R. Hoisington, Andrew J. Benros, Michael E. Stiller, John W. Kessler, Ronald C. Postolache, Teodor T. Curr Psychiatry Rep Complex Medical-Psychiatric Issues (MB Riba, Section Editor) PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Most common psychiatric manifestations include delirium, mood disorders, anxiety disorders, and posttraumatic stress disorder. “Long-COVID” non-syndromal presentations include “brain-fogginess,” autonomic instability, fatigue, and insomnia. SUMMARY: SARS-CoV-2 infection can trigger prior vulnerabilities based on the priming of microglia and other cells, induced or perpetuated by aging and mental and physical illnesses. COVID-19 could further induce priming of neuroimmunological substrates leading to exacerbated immune response and autoimmunity targeting structures in the central nervous system (CNS), in response to minor immune activating environmental exposures, including stress, minor infections, allergens, pollutants, and traumatic brain injury. Springer US 2021-10-01 2021 /pmc/articles/PMC8485771/ /pubmed/34648081 http://dx.doi.org/10.1007/s11920-021-01275-3 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Complex Medical-Psychiatric Issues (MB Riba, Section Editor)
Tizenberg, Boris N.
Brenner, Lisa A.
Lowry, Christopher A.
Okusaga, Olaoluwa O.
Benavides, David R.
Hoisington, Andrew J.
Benros, Michael E.
Stiller, John W.
Kessler, Ronald C.
Postolache, Teodor T.
Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title_full Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title_fullStr Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title_full_unstemmed Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title_short Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
title_sort biological and psychological factors determining neuropsychiatric outcomes in covid-19
topic Complex Medical-Psychiatric Issues (MB Riba, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485771/
https://www.ncbi.nlm.nih.gov/pubmed/34648081
http://dx.doi.org/10.1007/s11920-021-01275-3
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