Cargando…
Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485771/ https://www.ncbi.nlm.nih.gov/pubmed/34648081 http://dx.doi.org/10.1007/s11920-021-01275-3 |
_version_ | 1784577599254560768 |
---|---|
author | Tizenberg, Boris N. Brenner, Lisa A. Lowry, Christopher A. Okusaga, Olaoluwa O. Benavides, David R. Hoisington, Andrew J. Benros, Michael E. Stiller, John W. Kessler, Ronald C. Postolache, Teodor T. |
author_facet | Tizenberg, Boris N. Brenner, Lisa A. Lowry, Christopher A. Okusaga, Olaoluwa O. Benavides, David R. Hoisington, Andrew J. Benros, Michael E. Stiller, John W. Kessler, Ronald C. Postolache, Teodor T. |
author_sort | Tizenberg, Boris N. |
collection | PubMed |
description | PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Most common psychiatric manifestations include delirium, mood disorders, anxiety disorders, and posttraumatic stress disorder. “Long-COVID” non-syndromal presentations include “brain-fogginess,” autonomic instability, fatigue, and insomnia. SUMMARY: SARS-CoV-2 infection can trigger prior vulnerabilities based on the priming of microglia and other cells, induced or perpetuated by aging and mental and physical illnesses. COVID-19 could further induce priming of neuroimmunological substrates leading to exacerbated immune response and autoimmunity targeting structures in the central nervous system (CNS), in response to minor immune activating environmental exposures, including stress, minor infections, allergens, pollutants, and traumatic brain injury. |
format | Online Article Text |
id | pubmed-8485771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-84857712021-10-04 Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 Tizenberg, Boris N. Brenner, Lisa A. Lowry, Christopher A. Okusaga, Olaoluwa O. Benavides, David R. Hoisington, Andrew J. Benros, Michael E. Stiller, John W. Kessler, Ronald C. Postolache, Teodor T. Curr Psychiatry Rep Complex Medical-Psychiatric Issues (MB Riba, Section Editor) PURPOSE OF REVIEW: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. RECENT FINDINGS: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Most common psychiatric manifestations include delirium, mood disorders, anxiety disorders, and posttraumatic stress disorder. “Long-COVID” non-syndromal presentations include “brain-fogginess,” autonomic instability, fatigue, and insomnia. SUMMARY: SARS-CoV-2 infection can trigger prior vulnerabilities based on the priming of microglia and other cells, induced or perpetuated by aging and mental and physical illnesses. COVID-19 could further induce priming of neuroimmunological substrates leading to exacerbated immune response and autoimmunity targeting structures in the central nervous system (CNS), in response to minor immune activating environmental exposures, including stress, minor infections, allergens, pollutants, and traumatic brain injury. Springer US 2021-10-01 2021 /pmc/articles/PMC8485771/ /pubmed/34648081 http://dx.doi.org/10.1007/s11920-021-01275-3 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Complex Medical-Psychiatric Issues (MB Riba, Section Editor) Tizenberg, Boris N. Brenner, Lisa A. Lowry, Christopher A. Okusaga, Olaoluwa O. Benavides, David R. Hoisington, Andrew J. Benros, Michael E. Stiller, John W. Kessler, Ronald C. Postolache, Teodor T. Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title | Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title_full | Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title_fullStr | Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title_full_unstemmed | Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title_short | Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19 |
title_sort | biological and psychological factors determining neuropsychiatric outcomes in covid-19 |
topic | Complex Medical-Psychiatric Issues (MB Riba, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485771/ https://www.ncbi.nlm.nih.gov/pubmed/34648081 http://dx.doi.org/10.1007/s11920-021-01275-3 |
work_keys_str_mv | AT tizenbergborisn biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT brennerlisaa biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT lowrychristophera biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT okusagaolaoluwao biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT benavidesdavidr biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT hoisingtonandrewj biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT benrosmichaele biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT stillerjohnw biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT kesslerronaldc biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 AT postolacheteodort biologicalandpsychologicalfactorsdeterminingneuropsychiatricoutcomesincovid19 |