Safety, Tolerability, and Pharmacokinetics of a Novel Mitochondrial Modulator, TRC150094, in Overweight and Obese Subjects: A Randomized Phase-I Clinical Trial

TRC150094, a novel mitochondrial modulator, can restore metabolic flexibility by improving insulin resistance in preclinical studies. This study primarily aims to evaluate the safety, tolerability, and pharmacokinetics (PK) of oral TRC150094 after conducting two double-blind, randomized, Phase-I stu...

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Detalles Bibliográficos
Autores principales: Joshi, Deepa, Jamadarkhana, Prashant, Kumbhare, Suchit, Singh, Amarinder, Kotecha, Jignesh, Bunger, Deepak, Shiwalkar, Ajay, Mohanan, Anookh, Dutt, Chaitanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485898/
https://www.ncbi.nlm.nih.gov/pubmed/34603045
http://dx.doi.org/10.3389/fphar.2021.729424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485898/
https://www.ncbi.nlm.nih.gov/pubmed/34603045
http://dx.doi.org/10.3389/fphar.2021.729424

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