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Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

Background: Ageing and chronic kidney disease (CKD) affect pharmacokinetic (PK) parameters. Since mechanisms are related and remain unclear, cytochrome P450 (CYP) 3A and drug transporter activities were investigated in the elderly with or without CKD and compared to healthy adults using a microdose...

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Detalles Bibliográficos
Autores principales:	Rattanacheeworn, Punyabhorn, Kerr, Stephen J, Kittanamongkolchai, Wonngarm, Townamchai, Natavudh, Udomkarnjananun, Suwasin, Praditpornsilpa, Kearkiat, Thanusuwannasak, Thanundorn, Udomnilobol, Udomsak, Jianmongkol, Suree, Ongpipattanakul, Boonsri, Prueksaritanont, Thomayant, Avihingsanon, Yingyos, Chariyavilaskul, Pajaree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486002/ https://www.ncbi.nlm.nih.gov/pubmed/34603040 http://dx.doi.org/10.3389/fphar.2021.726669

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