Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth

Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific metabolites, accumulated within the TIF, could induce metabolic alterations of immune cells and shape the tumor microenviron...

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Detalles Bibliográficos
Autores principales: Vecchio, Eleonora, Caiazza, Carmen, Mimmi, Selena, Avagliano, Angelica, Iaccino, Enrico, Brusco, Teresa, Nisticò, Nancy, Maisano, Domenico, Aloisio, Annamaria, Quinto, Ileana, Renna, Maurizio, Divisato, Giuseppina, Romano, Simona, Tufano, Martina, D’Agostino, Massimo, Vigliar, Elena, Iaccarino, Antonino, Mignogna, Chiara, Andreozzi, Francesco, Mannino, Gaia Chiara, Spiga, Rosangela, Stornaiuolo, Mariano, Arcucci, Alessandro, Mallardo, Massimo, Fiume, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486041/
https://www.ncbi.nlm.nih.gov/pubmed/34604232
http://dx.doi.org/10.3389/fcell.2021.730726

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