An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence

Chemical-genetics (C-G) experiments can be used to identify interactions between inhibitory compounds and bacterial genes, potentially revealing the targets of drugs, or other functionally interacting genes and pathways. C-G experiments involve constructing a library of hypomorphic strains with esse...

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Detalles Bibliográficos
Autores principales: Dutta, Esha, DeJesus, Michael A., Ruecker, Nadine, Zaveri, Anisha, Koh, Eun-Ik, Sassetti, Christopher M., Schnappinger, Dirk, Ioerger, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486102/
https://www.ncbi.nlm.nih.gov/pubmed/34597304
http://dx.doi.org/10.1371/journal.pone.0257911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486102/
https://www.ncbi.nlm.nih.gov/pubmed/34597304
http://dx.doi.org/10.1371/journal.pone.0257911

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