Cargando…

An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence

Chemical-genetics (C-G) experiments can be used to identify interactions between inhibitory compounds and bacterial genes, potentially revealing the targets of drugs, or other functionally interacting genes and pathways. C-G experiments involve constructing a library of hypomorphic strains with esse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dutta, Esha, DeJesus, Michael A., Ruecker, Nadine, Zaveri, Anisha, Koh, Eun-Ik, Sassetti, Christopher M., Schnappinger, Dirk, Ioerger, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486102/ https://www.ncbi.nlm.nih.gov/pubmed/34597304 http://dx.doi.org/10.1371/journal.pone.0257911

Ejemplares similares

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression
por: Subramaniyam, Siddharth, et al.
Publicado: (2019)

A dose-response based model for statistical analysis of chemical genetic interactions in CRISPRi libraries
por: Choudhery, Sanjeevani, et al.
Publicado: (2023)

Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy
por: Koh, Eun-Ik, et al.
Publicado: (2022)

Statistical analysis of genetic interactions in Tn-Seq data
por: DeJesus, Michael A., et al.
Publicado: (2017)

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis
por: Bosch, Barbara, et al.
Publicado: (2021)

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
por: Li, Shuqi, et al.
Publicado: (2022)

TRANSIT - A Software Tool for Himar1 TnSeq Analysis
por: DeJesus, Michael A., et al.
Publicado: (2015)

A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data
por: DeJesus, Michael A, et al.
Publicado: (2013)

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis
por: DeJesus, Michael A., et al.
Publicado: (2017)

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism
por: Griffin, Jennifer E., et al.
Publicado: (2011)

A statistical method to identify recombination in bacterial genomes based on SNP incompatibility
por: Lai, Yi-Pin, et al.
Publicado: (2018)

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death
por: Zaveri, Anisha, et al.
Publicado: (2020)

GSHSite: Exploiting an Iteratively Statistical Method to Identify S-Glutathionylation Sites with Substrate Specificity
por: Chen, Yi-Ju, et al.
Publicado: (2015)

The role of irrigation in changing wheat yields and heat sensitivity in India
por: Zaveri, Esha, et al.
Publicado: (2019)

Functional Genomics Screening Utilizing Mutant Mouse Embryonic Stem Cells Identifies Novel Radiation-Response Genes
por: Loesch, Kimberly, et al.
Publicado: (2015)

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes
por: Lai, Yi-Pin, et al.
Publicado: (2020)

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis
por: Grover, Shipra, et al.
Publicado: (2020)

Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity
por: Su, Hongwei, et al.
Publicado: (2021)

Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction
por: Orsini, Caitlin A., et al.
Publicado: (2016)

Exploiting physico-chemical properties in string kernels
por: Toussaint, Nora C, et al.
Publicado: (2010)

Role and exploitation of underground chemical signaling in plants
por: Guerrieri, Alessandra, et al.
Publicado: (2019)

Modeling Site-Specific Nucleotide Biases Affecting Himar1 Transposon Insertion Frequencies in TnSeq Data Sets
por: Choudhery, Sanjeevani, et al.
Publicado: (2021)

Epidemics, pandemics, and social conflict: Lessons from the past and possible scenarios for COVID-19
por: Jedwab, Remi, et al.
Publicado: (2021)

Exploiting intrinsic fluctuations to identify model parameters
por: Zimmer, Christoph, et al.
Publicado: (2015)

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis
por: Bellerose, Michelle M., et al.
Publicado: (2020)

Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection
por: Gouzy, Alexandre, et al.
Publicado: (2014)

Exploiting syntactic and semantics information for chemical–disease relation extraction
por: Zhou, Huiwei, et al.
Publicado: (2016)

Exploitation of Trametes versicolor for bioremediation of endocrine disrupting chemicals in bioreactors
por: Pezzella, Cinzia, et al.
Publicado: (2017)

Successive Statistical and Structure-Based Modeling to Identify Chemically Novel Kinase Inhibitors
por: Burggraaff, Lindsey, et al.
Publicado: (2020)

Exploiting the brain's network structure in identifying ADHD subjects
por: Dey, Soumyabrata, et al.
Publicado: (2012)

Identifying and exploiting genes that potentiate the evolution of antibiotic resistance
por: Gifford, Danna, et al.
Publicado: (2018)

Exploiting geometric similarity for statistical quantification of fluorescence spatial patterns in bacterial colonies
por: Espeso, David R., et al.
Publicado: (2020)

Toward Exploiting Second-Order Feature Statistics for Arbitrary Image Style Transfer
por: Choi, Hyun-Chul
Publicado: (2022)

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis
por: Zhang, Yanjia J., et al.
Publicado: (2012)

Correction: Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis
por: Zhang, Yanjia J., et al.
Publicado: (2013)

A mathematical model for targeting chemicals to tissues by exploiting complex degradation
por: Gardiner, Bruce S, et al.
Publicado: (2011)

Exploiting chemical ecology to manage hyperparasitoids in biological control of arthropod pests
por: Cusumano, Antonino, et al.
Publicado: (2019)

Exploiting clock transitions for the chemical design of resilient molecular spin qubits
por: Giménez-Santamarina, Silvia, et al.
Publicado: (2020)

The Rip1 intramembrane protease contributes to iron and zinc homeostasis in Mycobacterium tuberculosis
por: Nelson, Samantha J., et al.
Publicado: (2023)

Identifying novel constrained elements by exploiting biased substitution patterns
por: Garber, Manuel, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_lpv978uolhsusg6pt7kb6vrpcj