Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation

Yes‐associated protein 1 (YAP1) and its paralogue PDZ‐binding motif (TAZ) play pivotal roles in cell proliferation, migration, and invasion, and abnormal activation of these TEAD transcriptional coactivators is found in diverse cancers in humans and mice. Targeting YAP1/TAZ signaling is thus a promi...

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Detalles Bibliográficos
Autores principales: Nakatani, Keisuke, Maehama, Tomohiko, Nishio, Miki, Otani, Junji, Yamaguchi, Keiko, Fukumoto, Miki, Hikasa, Hiroki, Hagiwara, Shinji, Nishina, Hiroshi, Mak, Tak Wah, Honma, Teruki, Kondoh, Yasumitsu, Osada, Hiroyuki, Yoshida, Minoru, Suzuki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486196/
https://www.ncbi.nlm.nih.gov/pubmed/34289205
http://dx.doi.org/10.1111/cas.15079

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