Improved plant cytosine base editors with high editing activity, purity, and specificity

Cytosine base editors (CBEs) are great additions to the expanding genome editing toolbox. To improve C‐to‐T base editing in plants, we first compared seven cytidine deaminases in the BE3‐like configuration in rice. We found A3A/Y130F‐CBE_V01 resulted in the highest C‐to‐T base editing efficiency in...

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Detalles Bibliográficos
Autores principales: Ren, Qiurong, Sretenovic, Simon, Liu, Guanqing, Zhong, Zhaohui, Wang, Jiaheng, Huang, Lan, Tang, Xu, Guo, Yachong, Liu, Li, Wu, Yuechao, Zhou, Jie, Zhao, Yuxin, Yang, Han, He, Yao, Liu, Shishi, Yin, Desuo, Mayorga, Rocio, Zheng, Xuelian, Zhang, Tao, Qi, Yiping, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486236/
https://www.ncbi.nlm.nih.gov/pubmed/34042262
http://dx.doi.org/10.1111/pbi.13635

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