Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.

BACKGROUND: Aflatoxin exposure has been shown to cause cell-mediated immune suppression and enhance HIV viral replication. Such immune suppression from aflatoxin can impair resistance to both infectious diseases and chronic infections. METHODS: Hazard ratios (HRs) with 95% confidence intervals (CI)...

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Autores principales: Keenan, John, Jolly, Pauline, Preko, Peter, Baidoo, Joseph, Wang, Jia-Sheng, Phillips, Timothy D., Williams, Jonathan H., McGwin, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486275/
https://www.ncbi.nlm.nih.gov/pubmed/34603628
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author Keenan, John
Jolly, Pauline
Preko, Peter
Baidoo, Joseph
Wang, Jia-Sheng
Phillips, Timothy D.
Williams, Jonathan H.
McGwin, Gerald
author_facet Keenan, John
Jolly, Pauline
Preko, Peter
Baidoo, Joseph
Wang, Jia-Sheng
Phillips, Timothy D.
Williams, Jonathan H.
McGwin, Gerald
author_sort Keenan, John
collection PubMed
description BACKGROUND: Aflatoxin exposure has been shown to cause cell-mediated immune suppression and enhance HIV viral replication. Such immune suppression from aflatoxin can impair resistance to both infectious diseases and chronic infections. METHODS: Hazard ratios (HRs) with 95% confidence intervals (CI) and a test for trend for opportunistic infections OI) among 141 HIV positive Ghanaians based on quartiles of aflatoxin B1 albumin adduct levels (AF-ALB) were calculated. FINDINGS: HRs were significantly higher for developing symptomatic TB (HR 3.30, 95% CI 1.34–8.11) for those in the highest AF-ALB quartile compared to the lowest. Significantly higher HRs were not observed for other infections investigated. CONCLUSIONS: Those with the highest levels AF-ALB from dietary intake have an increased hazard of symptomatic TB but not malaria, HBV, or pneumonia.
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spelling pubmed-84862752021-10-01 Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians. Keenan, John Jolly, Pauline Preko, Peter Baidoo, Joseph Wang, Jia-Sheng Phillips, Timothy D. Williams, Jonathan H. McGwin, Gerald Arch Clin Microbiol Article BACKGROUND: Aflatoxin exposure has been shown to cause cell-mediated immune suppression and enhance HIV viral replication. Such immune suppression from aflatoxin can impair resistance to both infectious diseases and chronic infections. METHODS: Hazard ratios (HRs) with 95% confidence intervals (CI) and a test for trend for opportunistic infections OI) among 141 HIV positive Ghanaians based on quartiles of aflatoxin B1 albumin adduct levels (AF-ALB) were calculated. FINDINGS: HRs were significantly higher for developing symptomatic TB (HR 3.30, 95% CI 1.34–8.11) for those in the highest AF-ALB quartile compared to the lowest. Significantly higher HRs were not observed for other infections investigated. CONCLUSIONS: Those with the highest levels AF-ALB from dietary intake have an increased hazard of symptomatic TB but not malaria, HBV, or pneumonia. 2011 /pmc/articles/PMC8486275/ /pubmed/34603628 Text en https://creativecommons.org/licenses/by/3.0/Under License of Creative Commons Attribution 3.0 License
spellingShingle Article
Keenan, John
Jolly, Pauline
Preko, Peter
Baidoo, Joseph
Wang, Jia-Sheng
Phillips, Timothy D.
Williams, Jonathan H.
McGwin, Gerald
Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title_full Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title_fullStr Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title_full_unstemmed Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title_short Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
title_sort association between aflatoxin b1 albumin adduct levels and tuberculosis infection among hiv+ ghanaians.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486275/
https://www.ncbi.nlm.nih.gov/pubmed/34603628
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