Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a prothrombotic disorder, which has been described as a rare adverse effect of the adenoviral-vectored coronavirus disease 2019 (COVID-19) vaccines. The diagnosis is confirmed by the detection of anti-platelet factor 4 (PF4) antibodies by...

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Autores principales: Wilting, Floor N.H., Kotsopoulos, Angela M.M., Platteel, Anouk C.M., van Oers, Jos A.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486363/
https://www.ncbi.nlm.nih.gov/pubmed/34646685
http://dx.doi.org/10.7759/cureus.17637
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author Wilting, Floor N.H.
Kotsopoulos, Angela M.M.
Platteel, Anouk C.M.
van Oers, Jos A.H.
author_facet Wilting, Floor N.H.
Kotsopoulos, Angela M.M.
Platteel, Anouk C.M.
van Oers, Jos A.H.
author_sort Wilting, Floor N.H.
collection PubMed
description Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a prothrombotic disorder, which has been described as a rare adverse effect of the adenoviral-vectored coronavirus disease 2019 (COVID-19) vaccines. The diagnosis is confirmed by the detection of anti-platelet factor 4 (PF4) antibodies by enzyme-linked immunosorbent assay (ELISA) or functional assay in individuals with the appropriate clinical history. Here, we report a case of a patient who presented with a severe intracerebral hemorrhage and thrombocytopenia 14 days after receiving the first dose of the Oxford-AstraZeneca COVID-19 vaccine, with negative PF4/heparin antibodies tested with ELISA, but positive heparin-induced platelet activation assay (HIPAA).
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spelling pubmed-84863632021-10-12 Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia Wilting, Floor N.H. Kotsopoulos, Angela M.M. Platteel, Anouk C.M. van Oers, Jos A.H. Cureus Infectious Disease Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a prothrombotic disorder, which has been described as a rare adverse effect of the adenoviral-vectored coronavirus disease 2019 (COVID-19) vaccines. The diagnosis is confirmed by the detection of anti-platelet factor 4 (PF4) antibodies by enzyme-linked immunosorbent assay (ELISA) or functional assay in individuals with the appropriate clinical history. Here, we report a case of a patient who presented with a severe intracerebral hemorrhage and thrombocytopenia 14 days after receiving the first dose of the Oxford-AstraZeneca COVID-19 vaccine, with negative PF4/heparin antibodies tested with ELISA, but positive heparin-induced platelet activation assay (HIPAA). Cureus 2021-09-01 /pmc/articles/PMC8486363/ /pubmed/34646685 http://dx.doi.org/10.7759/cureus.17637 Text en Copyright © 2021, Wilting et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Wilting, Floor N.H.
Kotsopoulos, Angela M.M.
Platteel, Anouk C.M.
van Oers, Jos A.H.
Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title_full Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title_fullStr Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title_full_unstemmed Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title_short Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia
title_sort intracerebral hemorrhage and thrombocytopenia after astrazeneca covid-19 vaccine: clinical and diagnostic challenges of vaccine-induced thrombotic thrombocytopenia
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486363/
https://www.ncbi.nlm.nih.gov/pubmed/34646685
http://dx.doi.org/10.7759/cureus.17637
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