SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients have the homozygous loss of the SMN1 gene and a variable number of SMN2 (generally 2–4 copies), i...

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Detalles Bibliográficos
Autores principales: Abiusi, Emanuela, Infante, Paola, Cagnoli, Cinzia, Lospinoso Severini, Ludovica, Pane, Marika, Coratti, Giorgia, Pera, Maria Carmela, D'Amico, Adele, Diano, Federica, Novelli, Agnese, Spartano, Serena, Fiori, Stefania, Baranello, Giovanni, Moroni, Isabella, Mora, Marina, Pasanisi, Maria Barbara, Pocino, Krizia, Le Pera, Loredana, D'Amico, Davide, Travaglini, Lorena, Ria, Francesco, Bruno, Claudio, Locatelli, Denise, Bertini, Enrico Silvio, Morandi, Lucia Ovidia, Mercuri, Eugenio, Di Marcotullio, Lucia, Tiziano, Francesco Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486378/
https://www.ncbi.nlm.nih.gov/pubmed/34542403
http://dx.doi.org/10.7554/eLife.68054

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