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Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First

Multiple sclerosis (MS) is an immune-mediated demyelinating disorder involving the central nervous system (CNS). It is common amongst young females. Although the exact cause of MS is yet unknown, viral infections such as EBV, environmental factors, and autoimmune and genetic mechanisms involving HLA...

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Autores principales: Rajapakshe, Ishani, Senanayake, Bimsara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486554/
https://www.ncbi.nlm.nih.gov/pubmed/34603807
http://dx.doi.org/10.1155/2021/1172870
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author Rajapakshe, Ishani
Senanayake, Bimsara
author_facet Rajapakshe, Ishani
Senanayake, Bimsara
author_sort Rajapakshe, Ishani
collection PubMed
description Multiple sclerosis (MS) is an immune-mediated demyelinating disorder involving the central nervous system (CNS). It is common amongst young females. Although the exact cause of MS is yet unknown, viral infections such as EBV, environmental factors, and autoimmune and genetic mechanisms involving HLA-DRB1 loci are implicated. Familial MS is reported from some geographic locations and ethnic groups but is thought to be rare in Asia. In this paper, we present both a Sri Lankan mother and her son, with clinically definite MS conforming to McDonald's 2017 clinical and MAGNIMS 2016 radiological criteria. Both had oligoclonal bands in their CSF (OCB-IEF) with no serum bands indicating intrathecal production and were negative for AQP4 and MOG IgG serology. Familial MS is more common among siblings, with sister-sister relationship having the highest rate. The lowest relation was amongst father-son and mother-son pairs. Amongst siblings, the risk of MS is between 3.5% and 4.7%. Inherited factors rather than common environmental exposure influence susceptibility in such cases. To the best of our knowledge, MS occurring in a mother-son pair has not been reported before either from Sri Lanka or South Asia.
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spelling pubmed-84865542021-10-02 Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First Rajapakshe, Ishani Senanayake, Bimsara Case Rep Neurol Med Case Report Multiple sclerosis (MS) is an immune-mediated demyelinating disorder involving the central nervous system (CNS). It is common amongst young females. Although the exact cause of MS is yet unknown, viral infections such as EBV, environmental factors, and autoimmune and genetic mechanisms involving HLA-DRB1 loci are implicated. Familial MS is reported from some geographic locations and ethnic groups but is thought to be rare in Asia. In this paper, we present both a Sri Lankan mother and her son, with clinically definite MS conforming to McDonald's 2017 clinical and MAGNIMS 2016 radiological criteria. Both had oligoclonal bands in their CSF (OCB-IEF) with no serum bands indicating intrathecal production and were negative for AQP4 and MOG IgG serology. Familial MS is more common among siblings, with sister-sister relationship having the highest rate. The lowest relation was amongst father-son and mother-son pairs. Amongst siblings, the risk of MS is between 3.5% and 4.7%. Inherited factors rather than common environmental exposure influence susceptibility in such cases. To the best of our knowledge, MS occurring in a mother-son pair has not been reported before either from Sri Lanka or South Asia. Hindawi 2021-09-23 /pmc/articles/PMC8486554/ /pubmed/34603807 http://dx.doi.org/10.1155/2021/1172870 Text en Copyright © 2021 Ishani Rajapakshe and Bimsara Senanayake. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rajapakshe, Ishani
Senanayake, Bimsara
Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title_full Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title_fullStr Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title_full_unstemmed Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title_short Familial Multiple Sclerosis in a Mother and Son Pair: A Sri Lankan and a South Asian First
title_sort familial multiple sclerosis in a mother and son pair: a sri lankan and a south asian first
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486554/
https://www.ncbi.nlm.nih.gov/pubmed/34603807
http://dx.doi.org/10.1155/2021/1172870
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